5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil

Base Information

Chemical Name:5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil
CAS No.:809232-62-0
Molecular Formula:C₄₀H₅₃FN₄O₉S₂
Molecular Weight:817.013
Hs Code.:

5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil

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Chemical Property of 5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil

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Technology Process of 5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil

There total 6 articles about 5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10212-13-2
3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine

: 809232-62-0
5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1: iodonium chloride / CH₂Cl₂

2: (CH₃CN)2PdCl₂ / dimethylformamide

3: NBS; triphenylphosphorus / dimethylformamide

4: DIEA / acetonitrile

With N-Bromosuccinimide; iodonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2004.09.145

Reference yield:

: 56287-17-3,69123-94-0,784-71-4
2'-deoxy-2'-fluorouridine

: 809232-62-0
5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine

2: iodonium chloride / CH₂Cl₂

3: (CH₃CN)2PdCl₂ / dimethylformamide

4: NBS; triphenylphosphorus / dimethylformamide

5: DIEA / acetonitrile

With pyridine; N-Bromosuccinimide; iodonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2004.09.145

Reference yield:

: 565226-18-8
((2R,3R,4R,5R)-3-acetoxy-4-fluoro-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate

: 809232-62-0
5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil

Guidance literature:: Multi-step reaction with 3 steps

1: (CH₃CN)2PdCl₂ / dimethylformamide

2: NBS; triphenylphosphorus / dimethylformamide

3: DIEA / acetonitrile

With N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2004.09.145