N-(furan-2-ylmethyl)-2-hydroxybenzamide

Base Information

• Chemical Name: N-(furan-2-ylmethyl)-2-hydroxybenzamide
• CAS No.: 13156-92-8
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• DSSTox Substance ID: DTXSID601330755
• ChEMBL ID: CHEMBL1558525
• Mol file: 13156-92-8.mol

Synonyms:13156-92-8;N-(furan-2-ylmethyl)-2-hydroxybenzamide;N-(2-furylmethyl)-2-hydroxybenzamide;N-Furan-2-ylmethyl-2-hydroxy-benzamide;Oprea1_869859;MLS001206673;CHEMBL1558525;DTXSID601330755;HMS2824L06;BBL008253;MFCD02933958;STK733891;AKOS000207177;SMR000519096;VS-01867;N-[(furan-2-yl)methyl]-2-hydroxybenzamide;CS-0313715;SR-01000534476;SR-01000534476-1

Chemical Property of N-(furan-2-ylmethyl)-2-hydroxybenzamide

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 217.07389321
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Furylmethyl)-2-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NCC2=CC=CO2)O

Technology Process of N-(furan-2-ylmethyl)-2-hydroxybenzamide

There total 3 articles about N-(furan-2-ylmethyl)-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

furan-2-ylmethanamine (617-89-0) + (1H-benzo[d][1,2,3]triazol-1-yl)(2-hydroxyphenyl)methanone (347370-91-6) → N-(furan-2-ylmethyl)-2-hydroxybenzamide (13156-92-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 0.5h;

DOI:10.1021/jo052293q

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → N-(furan-2-ylmethyl)-2-hydroxybenzamide (13156-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / SOCl₂ / tetrahydrofuran / 2 h / 20 °C

2: 83 percent / triethylamine / tetrahydrofuran / 0.5 h

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1021/jo052293q

Reference yield:

furan-2-ylmethanamine (617-89-0) + methyl salicylate (119-36-8,8024-54-2) → N-(furan-2-ylmethyl)-2-hydroxybenzamide (13156-92-8)

Guidance literature:

Heating;

DOI:10.1016/j.jssc.2009.07.062

upstream raw materials:

furan-2-ylmethanamine

(1H-benzo[d][1,2,3]triazol-1-yl)(2-hydroxyphenyl)methanone

salicylic acid

methyl salicylate

Downstream raw materials:

1,3,5-tris{[(2'-furfurylaminoformyl)phenoxyl]methyl}-2,4,6-trimethylbenzene

1,1,1-tris{[(2'-furfurylaminoformyl)phenoxy]methyl}propane

1,1,1,1-tetrakis([(2'-(2-furfurylaminoformyl))phenoxyl]methyl)methane

1,2-bis[[(2'-furfurylaminoformyl)phenoxyl]methyl]benzene

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