5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione

Base Information

• Chemical Name: 5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione
• CAS No.: 13177-71-4
• Molecular Formula: C6H4N2O3
• Molecular Weight: 152.109
• Mol file: 13177-71-4.mol

Synonyms:FURO[3,2-D]PYRIDAZINE-4,7-DIOL;

Chemical Property of 5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione

Chemical Property:

• PSA: 78.86000
• LogP: -0.19060

Purity/Quality:

>98% ^*data from raw suppliers

Furo[2,3-d]pyridazine-4,7-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione

There total 5 articles about 5,6-dihydrofuro[3,2-d]pyridazine-4,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 3-methoxycarbonylfuran-2-carboxylate (52900-79-5) → 5,6-dihydrofuro[2,3-d]pyridazine-4,7-dione (13177-71-4)

Guidance literature:

With hydrazine hydrate; In ethanol; water; for 6h; Reflux;

DOI:10.1021/jm900309j

Reference yield:

furan-2,3-dicarboxylic acid (4282-24-0) → 5,6-dihydrofuro[2,3-d]pyridazine-4,7-dione (13177-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 16 h / 20 °C

2.1: hydrazine / ethanol; water / 5 - 6 h / Heating / reflux

2.2: 4 h / Heating / reflux

With thionyl chloride; hydrazine; In ethanol; water;

Reference yield:

3-Furoic acid (488-93-7) → 5,6-dihydrofuro[2,3-d]pyridazine-4,7-dione (13177-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran; hexanes / 2.5 h / -78 - -10 °C

2: chloro-trimethyl-silane / 15.5 h / 20 °C

3: hydrazine / ethanol / 5.5 h / Heating / reflux

With n-butyllithium; chloro-trimethyl-silane; hydrazine; In tetrahydrofuran; hexanes; ethanol;

upstream raw materials:

furan-2,3-dicarboxylic acid dihydrazide

methyl 3-methoxycarbonylfuran-2-carboxylate

furan-2,3-dicarboxylic acid

3-Furoic acid

Downstream raw materials:

Furo<2,3-d>pyridazin

4-(4-methoxyphenylamino)-7-chlorofuro-[2,3-d]pyridazine

4-chloroanilino-7-chlorofuro[2,3-d]pyridazine

4-chloro-7-[N-(4-chlorophenyl)amino]-[2,3-d]furopyridazine