2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene

Base Information

• Chemical Name: 2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene
• CAS No.: 1004322-78-4
• Molecular Formula: C₁₂H₁₇F₃O₂Si
• Molecular Weight: 278.346
• Mol file: 1004322-78-4.mol

Synonyms:

Chemical Property of 2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene

There total 24 articles about 2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-methoxyphenyltrimethylsilane (1004322-70-6) → 2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene (1004322-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: water; acetone / 25 h / Photolysis

2: pyridine / 1 h / 50 °C / Inert atmosphere

3: caesium carbonate; acetone / 12 h / Photolysis

With pyridine; water; caesium carbonate; acetone;

DOI:10.1021/jo300290v

Reference yield:

4-methoxy-2-trimethylsilylphenol (85630-29-1) → 2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene (1004322-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / 50 °C / Inert atmosphere

2: caesium carbonate; acetone / 12 h / Photolysis

With pyridine; caesium carbonate; acetone;

DOI:10.1021/jo300290v

Reference yield:

4-methoxy-2-trimethylsilylphenyl methanesulfonate (1366440-80-3) → 2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene (1004322-78-4)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; acetone / 8 h / Photolysis

2: pyridine / 1 h / 50 °C / Inert atmosphere

3: caesium carbonate; acetone / 12 h / Photolysis

With pyridine; caesium carbonate; acetone;

DOI:10.1021/jo300290v

upstream raw materials:

2-chloro-5-methoxyphenyltrimethylsilane

2,2,2-trifluoroethanol

allyl-trimethyl-silane

benzene