(S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol

Base Information

Chemical Name:(S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol
CAS No.:116355-96-5
Molecular Formula:C₂₈H₄₁F₃O₂
Molecular Weight:466.628
Hs Code.:

(S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol

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Chemical Property of (S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol

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Technology Process of (S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol

There total 6 articles about (S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116355-90-9
2-methyl-4-phenylsulfonyl-3-trifluoromethylbutane-1,2-diol

: 116355-96-5,116404-53-6,117467-30-8
(S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

2: 89 percent / LDA, MgBr₂, / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

3: 67 percent / 3percent Na-Hg, Na₂HPO₄, / methanol; tetrahydrofuran / 0 °C

4: 98 percent / p-TsOH, / methanol / Ambient temperature

5: 1.)photoirradiation, EtOH-benzene, 5 min; 2.)reflux, 1h

With disodium hydrogenphosphate; sodium amalgam; toluene-4-sulfonic acid; magnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4039(00)80061-1

Reference yield:

: 116740-30-8
2-methyl-4 phenylsulfonyl-3-trifluoromethyl-2-butanol tetrahydropyranyl ether

: 116355-96-5,116404-53-6,117467-30-8
(S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / LDA, MgBr₂, / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

2: 67 percent / 3percent Na-Hg, Na₂HPO₄, / methanol; tetrahydrofuran / 0 °C

3: 98 percent / p-TsOH, / methanol / Ambient temperature

4: 1.)photoirradiation, EtOH-benzene, 5 min; 2.)reflux, 1h

With disodium hydrogenphosphate; sodium amalgam; toluene-4-sulfonic acid; magnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4039(00)80061-1

Reference yield:

: 116355-89-6
2-methyl-4-phenylsulfonyl-2-triethylsiloxy-3-trifluoromethylbutyric acid ethyl ester

: 116355-96-5,116404-53-6,117467-30-8
(S)-3-[2-[(1R,3aS)-1-((E)-(R)-5-Hydroxy-1,5-dimethyl-4-trifluoromethyl-hex-2-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1,) DIBAL, 2,) 10percent HCl / 1.)Et₂O 2.) MeOH

3: 89 percent / LDA, MgBr₂, / tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

4: 67 percent / 3percent Na-Hg, Na₂HPO₄, / methanol; tetrahydrofuran / 0 °C

5: 98 percent / p-TsOH, / methanol / Ambient temperature

6: 1.)photoirradiation, EtOH-benzene, 5 min; 2.)reflux, 1h

With hydrogenchloride; disodium hydrogenphosphate; sodium amalgam; diisobutylaluminium hydride; toluene-4-sulfonic acid; magnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4039(00)80061-1