Technology Process of methyl 2-(2-chloro-5-(dimethylcarbamoyl)phenylcarbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate
There total 13 articles about methyl 2-(2-chloro-5-(dimethylcarbamoyl)phenylcarbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trans-di(μ-acetato)-bis[o-(di-o-tolylphosphino)benzyl]-dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
under 760.051 Torr;
Sealed vial;
Microwave irradiation;
Heating;
DOI:10.1021/jm2007084
- Guidance literature:
-
Multi-step reaction with 9 steps
1: lithium hydroxide monohydrate; water / tetrahydrofuran / 48 h / 50 °C
2: polyphosphoric acid; celite / toluene / 5 h / 110 °C
3: N,N-dimethyl-formamide / 20 °C
4: potassium carbonate / N,N-dimethyl-formamide / 50 °C
5: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C
6: thionyl chloride / 2 h / 80 °C
7: pyridine / tetrahydrofuran / 0 - 20 °C
8: caesium carbonate / N,N-dimethyl-formamide / 20 °C
9: trans-di(μ-acetato)-bis[o-(di-o-tolylphosphino)benzyl]-dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 760.05 Torr / Sealed vial; Microwave irradiation; Heating
With
pyridine; thionyl chloride; trans-di(μ-acetato)-bis[o-(di-o-tolylphosphino)benzyl]-dipalladium(II); lithium hydroxide monohydrate; water; potassium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2007084
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 50 °C
2: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 50 °C
3: thionyl chloride / 2 h / 80 °C
4: pyridine / tetrahydrofuran / 0 - 20 °C
5: caesium carbonate / N,N-dimethyl-formamide / 20 °C
6: trans-di(μ-acetato)-bis[o-(di-o-tolylphosphino)benzyl]-dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 760.05 Torr / Sealed vial; Microwave irradiation; Heating
With
pyridine; thionyl chloride; trans-di(μ-acetato)-bis[o-(di-o-tolylphosphino)benzyl]-dipalladium(II); lithium hydroxide monohydrate; water; potassium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2007084
