Adoc₂-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl

Base Information

• Chemical Name: Adoc₂-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl
• CAS No.: 148797-62-0
• Molecular Formula: C₆₈H₈₅N₅O₁₃
• Molecular Weight: 1180.45
• Mol file: 148797-62-0.mol

Synonyms:

Chemical Property of Adoc₂-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Adoc₂-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl

There total 5 articles about Adoc₂-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

H-Gly-Gly-Phe-Leu-OBzl (69729-07-3) + C48H56N2O11 → Adoc2-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl (148797-62-0)

Guidance literature:

In N,N-dimethyl-formamide; for 48h;

DOI:10.3891/acta.chem.scand.47-0374

Reference yield:

L-phenylalanyl-L-leucine benzyl ester (63649-15-0) → Adoc2-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl (148797-62-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 67 percent / dimethylformamide / 24 h

2: TFA / 5 h

3: 63 percent / dimethylformamide / 48 h

4: 250 mg / TFA / 0 °C

5: 69 percent / dimethylformamide / 48 h

With trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.3891/acta.chem.scand.47-0374

Reference yield:

(S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate (73994-89-5) → Adoc2-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl (148797-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / dimethylformamide / 48 h

2: 250 mg / TFA / 0 °C

3: 69 percent / dimethylformamide / 48 h

With trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.3891/acta.chem.scand.47-0374

upstream raw materials:

H-Gly-Gly-Phe-Leu-OBzl

L-phenylalanyl-L-leucine benzyl ester

(S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate

Adoc₂-Gly-Phe-Leu-OBzl