Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

Base Information

Chemical Name:Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester
CAS No.:88526-18-5
Molecular Formula:C₄₇H₅₇O₁₃PS
Molecular Weight:893.002
Hs Code.:

Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

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Chemical Property of Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

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Technology Process of Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

There total 15 articles about Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 88587-02-4
Benzoic acid (1R,2R,4S)-2-[(S)-2-benzenesulfonyl-6-(tetrahydro-pyran-2-yloxy)-heptanoyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 88526-18-5
Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

Guidance literature:: With dmap; triethylamine; acetonitrile;

Reference yield:

: 2973-86-6
lithium thiophenoxide

: 88526-18-5
Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 25 °C

2: m-Cl-C₆H₄-CO₃H / CHCl₃ / -10 °C

3: H₂ / Pd/C / methanol

4: H(+)

5: nBuLi / tetrahydrofuran / -78 °C

6: LiN(SiMe₃)2 / tetrahydrofuran / -78 - -20 °C

7: acetic acid / 0 °C

8: 1,8-diazabicyclo<5.4.0>undec-7-en / CH₂Cl₂ / 0 °C

9: 94 percent / MeCN, NEt₃, 4-dimethylaminopyridine

With dmap; n-butyllithium; hydrogen; hydrogen cation; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; acetonitrile; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetic acid;

Reference yield:

: 88526-13-0
(S)-5-benzyloxyhexanol

: 88526-18-5
Benzoic acid (1R,2R,4S)-2-[(E)-(S)-2-benzenesulfonyl-1-(diphenoxy-phosphoryloxy)-6-(tetrahydro-pyran-2-yloxy)-hept-1-enyl]-4-(2-methoxy-ethoxymethoxy)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine

2: tetrahydrofuran / 25 °C

3: m-Cl-C₆H₄-CO₃H / CHCl₃ / -10 °C

4: H₂ / Pd/C / methanol

5: H(+)

6: nBuLi / tetrahydrofuran / -78 °C

7: LiN(SiMe₃)2 / tetrahydrofuran / -78 - -20 °C

8: acetic acid / 0 °C

9: 1,8-diazabicyclo<5.4.0>undec-7-en / CH₂Cl₂ / 0 °C

10: 94 percent / MeCN, NEt₃, 4-dimethylaminopyridine

With dmap; n-butyllithium; hydrogen; hydrogen cation; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; acetonitrile; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; chloroform; acetic acid;