4-Bromophthalaldehyde

Base Information

• Chemical Name: 4-Bromophthalaldehyde
• CAS No.: 13209-32-0
• Molecular Formula: C8H5BrO2
• Molecular Weight: 213.03
• Hs Code.: 2913000090
• Mol file: 13209-32-0.mol

Synonyms:4-bromo-phthalaldehyde;4-bromo-1,2-benzenedicarboxaldehyde;4-bromophtalaldehyde;4-Brom-o-phthalaldehyd;4-bromo-benzene-1,2-dicarbaldehyde;1,2-Benzenedicarboxaldehyde,4-bromo;4-Brom-phthalaldehyd;

Chemical Property of 4-Bromophthalaldehyde

Chemical Property:

• Melting Point: 99-100 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
• Boiling Point: 326.3±32.0 °C(Predicted)
• PSA: 34.14000
• Density: 1.652±0.06 g/cm3(Predicted)
• LogP: 2.07410

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromophthalaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromophthalaldehyde

There total 11 articles about 4-Bromophthalaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4,α,α,α',α'-pentabromo-o-xylene (4235-46-5) → 4-bromophthalaldehyde (13209-32-0)

Guidance literature:

4,α,α,α',α'-pentabromo-o-xylene; With sulfuric acid;

With water; sodium hydrogencarbonate; Product distribution / selectivity;

Reference yield: 88.0%

4-bromo-2-(hydroxymethyl)benzyl alcohol (171011-37-3) → 4-bromophthalaldehyde (13209-32-0)

Guidance literature:

4-bromo-2-(hydroxymethyl)benzyl alcohol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1016/j.tet.2017.11.035

Reference yield: 88.0%

→ 4-bromophthalaldehyde (13209-32-0)

Guidance literature:

Product distribution / selectivity;

upstream raw materials:

5-bromo-1,3-dimethoxy-phthalan

4-bromo-1,2-bis-diacetoxymethyl-benzene

4,α,α,α',α'-pentabromo-o-xylene

1,4-dibromo-2-(dimethoxymethyl)benzene

Downstream raw materials:

5-bromo-1,3-dihydroisobenzofuran

6-bromophthalazine

ethyl 7-bromoisoquinoline-3-carboxylate

C₂₄H₁₇O₂Br

Refernces

• 1、 -. "CYCLIC PEPTIDE ANALOGS OF MELANOCORTIN AND AMANITIN AND METHODS OF MAKING SUCH". Paragraph 0114; 0118; 0124. . Retrieved 2021/01/29.
• 2、 Gu, Yang,Natoli, Sean N.,Liu, Zhennan,Clark, Douglas S.,Hartwig, John F.. "Site-Selective Functionalization of (sp3)C?H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor". supporting information. p. 13954 - 13960. Retrieved 2019/08/30.