3(S)-Benzamido-2(R)-hydroxybenzenepropionic acid (2aR,4S,4aS,6R,9S,11S, 12S,12aR,12bS)-6-acetoxy-12b-(cyclopropylcarbonyloxy)-12-(2,4-difluorobenzoyloxy)-4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11- me

Base Information

Chemical Name:3(S)-Benzamido-2(R)-hydroxybenzenepropionic acid (2aR,4S,4aS,6R,9S,11S, 12S,12aR,12bS)-6-acetoxy-12b-(cyclopropylcarbonyloxy)-12-(2,4-difluorobenzoyloxy)-4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11- me
CAS No.:230972-99-3
Molecular Formula:C₄₉H₅₁F₂NO₁₄
Molecular Weight:915.939
Hs Code.:

3(S)-Benzamido-2(R)-hydroxybenzenepropionic acid (2aR,4S,4aS,6R,9S,11S, 12S,12aR,12bS)-6-acetoxy-12b-(cyclopropylcarbonyloxy)-12-(2,4-difluorobenzoyloxy)-4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11- me

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Suppliers and Price of 3(S)-Benzamido-2(R)-hydroxybenzenepropionic acid (2aR,4S,4aS,6R,9S,11S, 12S,12aR,12bS)-6-acetoxy-12b-(cyclopropylcarbonyloxy)-12-(2,4-difluorobenzoyloxy)-4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11- me

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Chemical Property of 3(S)-Benzamido-2(R)-hydroxybenzenepropionic acid (2aR,4S,4aS,6R,9S,11S, 12S,12aR,12bS)-6-acetoxy-12b-(cyclopropylcarbonyloxy)-12-(2,4-difluorobenzoyloxy)-4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11- me

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Technology Process of 3(S)-Benzamido-2(R)-hydroxybenzenepropionic acid (2aR,4S,4aS,6R,9S,11S, 12S,12aR,12bS)-6-acetoxy-12b-(cyclopropylcarbonyloxy)-12-(2,4-difluorobenzoyloxy)-4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11- me

There total 4 articles about 3(S)-Benzamido-2(R)-hydroxybenzenepropionic acid (2aR,4S,4aS,6R,9S,11S, 12S,12aR,12bS)-6-acetoxy-12b-(cyclopropylcarbonyloxy)-12-(2,4-difluorobenzoyloxy)-4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11- me which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 330996-81-1
C₆₁H₇₉F₂NO₁₄Si₂

: 230972-99-3
C₄₉H₅₁F₂NO₁₄

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran;
DOI:10.1016/S0968-0896(00)00233-9

Reference yield:

: 160768-77-4
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

: 230972-99-3
C₄₉H₅₁F₂NO₁₄

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilamide / tetrahydrofuran / 0.25 h / -78 °C

2: LiOH*H₂O / tetrahydrofuran; H₂O / 20 °C

3: dicyclohexylcarbodiimide; DMAP / toluene

4: HF*pyridine / tetrahydrofuran

With dmap; lithium hydroxide; pyridine hydrogenfluoride; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; water; toluene;
DOI:10.1016/S0968-0896(00)00233-9

Reference yield:

: 330996-56-0
C₅₄H₇₇NO₁₃Si₂

: 230972-99-3
C₄₉H₅₁F₂NO₁₄

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide; DMAP / toluene

2: HF*pyridine / tetrahydrofuran

With dmap; pyridine hydrogenfluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene;
DOI:10.1016/S0968-0896(00)00233-9