160768-77-4

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 160768-75-2 2'-O-(tert-butyldimethylsilyl)-4-O-deacetyl-2-O-debenzoyl-7-O-(triethylsilyl)paclitaxel 
• 114655-02-6 2'-O-(tert-butyldimethylsilyl)paclitaxel 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 994-30-9 triethylsilyl chloride 
• 156413-61-5 2'-(tert-butyldimethylsilyl)-7-(triethylsilyl)paclitaxel 
• 33069-62-4 taxol 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 162459-97-4 C₅₅H₇₇NO₁₄Si₂ 
• 330996-49-1 C₅₅H₇₅NO₁₄Si₂ 
• 160768-81-0 C₅₇H₇₇NO₁₂Si₂ 
• 160768-82-1 C₅₅H₇₅NO₁₁Si₂ 
• 160768-79-6 C₅₁H₇₁NO₁₂Si₂ 
• 330996-43-5 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-4-deacetyl-4-(O-benzylglutaryl)-paclitaxel 
• 330998-83-9 C₆₄H₇₉Cl₂NO₁₄Si₂ 
• 330996-81-1 C₆₁H₇₉F₂NO₁₄Si₂ 
• 330996-85-5 C₆₁H₇₉Cl₂NO₁₄Si₂ 
• 330996-74-2 C₆₁H₈₀N₄O₁₄Si₂ 
• 330996-42-4 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-4-(O-benzylglutaryl)-paclitaxel 
• 330996-79-7 C₆₁H₈₀ClNO₁₄Si₂ 
• 230283-87-1 C₆₃H₈₇NO₁₆Si₂ 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel paclitaxel (Taxol) D-ring modified analogues

The semisynthesis and biological activity of paclitaxel (Taxol) analogues in which the oxygen atom in ring D is substituted by a sulfur or a selenium atom is presented. These derivatives were synthesized and tested in order to make more transparent the role of the oxetane ring in the biological activity of paclitaxel. The sulfur derivatives were found to be less active than paclitaxel in biological assays, while the selenium derivative could not be converted to its 4-acyl analogue. The results with the sulfur analogues suggest that the oxygen atom in the oxetane ring plays an important role in the mechanism by which paclitaxel exhibits its anticancer activity.

Selective C-2 and C-4 deacylation and acylation of taxol: The first synthesis of a C-4 substituted taxol analogue

Hydrolytic procedures for selective 2-debenzoylation and 2,4-dideacylation of 2'-O-tert-butyldimethylsilyl-7-O-(triethylsilyl)taxol are reported. The first synthesis and biological evaluation of a 4-substituted analogue, 4-deacetyl-4-isobutanoyltaxol, is

Synthesis and Biological Evaluation of 4-Deacetoxypaclitaxel

4-Deacetoxypaclitaxel (9) has been prepared in seven steps from paclitaxel (Taxol).It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.