Defluoro Levofloxacin

Base Information

• Chemical Name: Defluoro Levofloxacin
• CAS No.: 117620-85-6
• Molecular Formula: C₁₈H₂₁N₃O₄
• Molecular Weight: 343.382
• Hs Code.: 2934990002
• Mol file: 117620-85-6.mol

Synonyms:

Chemical Property of Defluoro Levofloxacin

Chemical Property:

• Melting Point: 217-223?C
• Boiling Point: 561.4±50.0 °C(Predicted)
• PKA: 5?+-.0.40(Predicted)
• Density: 1.43±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated, Heated)

Purity/Quality:

95-99% ^*data from raw suppliers

Defluoro levofloxacin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Nonfluorinated analog of Levofloxacin (L360000). Levofloxacin USP Related Compound F. Nonfluorinated analog of Levofloxacin

Technology Process of Defluoro Levofloxacin

There total 5 articles about Defluoro Levofloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4-trifluoro-benzoyl chloride (157373-08-5) → levofloxacin (117620-85-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 65 percent / nBuLi / tetrahydrofuran / -78 - 20 °C

2.1: Ac₂O / 110 °C

2.2: 78 percent / CH₂Cl₂ / 0 - 20 °C

3.1: 73 percent / NaH / tetrahydrofuran / 0 - 20 °C

4.1: 89 percent / aq. KOH / tetrahydrofuran / Heating

5.1: pyridine / 110 °C

With pyridine; potassium hydroxide; n-butyllithium; acetic anhydride; sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00399-8

Reference yield:

ethyl 3-(2,3,4-trifluorophenyl)-3-oxopropanoate (157766-27-3) → levofloxacin (117620-85-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Ac₂O / 110 °C

1.2: 78 percent / CH₂Cl₂ / 0 - 20 °C

2.1: 73 percent / NaH / tetrahydrofuran / 0 - 20 °C

3.1: 89 percent / aq. KOH / tetrahydrofuran / Heating

4.1: pyridine / 110 °C

With pyridine; potassium hydroxide; acetic anhydride; sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00399-8

Reference yield:

ethyl 10-fluoro-2,3-dihydro-3-(S)-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate (431058-46-7) → levofloxacin (117620-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / aq. KOH / tetrahydrofuran / Heating

2: pyridine / 110 °C

With pyridine; potassium hydroxide; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00399-8

upstream raw materials:

1-methyl-piperazine

9-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid

2,3,4-trifluoro-benzoyl chloride

ethyl 3-(2,3,4-trifluorophenyl)-3-oxopropanoate

Refernces