Defluoro Levofloxacin

Base Information

Chemical Name:Defluoro Levofloxacin
CAS No.:117620-85-6
Molecular Formula:C₁₈H₂₁N₃O₄
Molecular Weight:343.382
Hs Code.:2934990002
Mol file:117620-85-6.mol

Synonyms:

Suppliers and Price of Defluoro Levofloxacin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Defluoro levofloxacin
1mg
$ 608.00

TRC
DefluoroLevofloxacin
10mg
$ 1295.00

Biosynth Carbosynth
Defluoro levofloxacin
10 mg
$ 1528.80

Biosynth Carbosynth
Defluoro levofloxacin
5 mg
$ 840.90

Biosynth Carbosynth
Defluoro levofloxacin
2 mg
$ 462.50

Biosynth Carbosynth
Defluoro levofloxacin
1 mg
$ 254.40

American Custom Chemicals Corporation
LEVOFLOXACIN RELATED COMPOUND F 95.00%
5MG
$ 503.69

Total 20 raw suppliers

Chemical Property of Defluoro Levofloxacin

Chemical Property:

Melting Point:217-223?C
Boiling Point:561.4±50.0 °C(Predicted)
PKA:5?+-.0.40(Predicted)
Density:1.43±0.1 g/cm3(Predicted)
Storage Temp.:Refrigerator, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

Defluoro levofloxacin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Nonfluorinated analog of Levofloxacin (L360000). Levofloxacin USP Related Compound F. Nonfluorinated analog of Levofloxacin

Technology Process of Defluoro Levofloxacin

There total 5 articles about Defluoro Levofloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157373-08-5
2,3,4-trifluoro-benzoyl chloride

: 117620-85-6
levofloxacin

Guidance literature:: Multi-step reaction with 5 steps

1.1: 65 percent / nBuLi / tetrahydrofuran / -78 - 20 °C

2.1: Ac₂O / 110 °C

2.2: 78 percent / CH₂Cl₂ / 0 - 20 °C

3.1: 73 percent / NaH / tetrahydrofuran / 0 - 20 °C

4.1: 89 percent / aq. KOH / tetrahydrofuran / Heating

5.1: pyridine / 110 °C

With pyridine; potassium hydroxide; n-butyllithium; acetic anhydride; sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00399-8

Reference yield:

: 157766-27-3
ethyl 3-(2,3,4-trifluorophenyl)-3-oxopropanoate

: 117620-85-6
levofloxacin

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ac₂O / 110 °C

1.2: 78 percent / CH₂Cl₂ / 0 - 20 °C

2.1: 73 percent / NaH / tetrahydrofuran / 0 - 20 °C

3.1: 89 percent / aq. KOH / tetrahydrofuran / Heating

4.1: pyridine / 110 °C

With pyridine; potassium hydroxide; acetic anhydride; sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00399-8

Reference yield:

: 431058-46-7
ethyl 10-fluoro-2,3-dihydro-3-(S)-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate

: 117620-85-6
levofloxacin

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / aq. KOH / tetrahydrofuran / Heating

2: pyridine / 110 °C

With pyridine; potassium hydroxide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00399-8