3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:106502-50-5
Molecular Formula:C₄₂H₄₀N₄O₈
Molecular Weight:728.802
Hs Code.:

3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 1 articles about 3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 94189-75-0
N³-benzoyl thymidine

: 106502-49-2
C₂₅H₂₃N₂O₂⁽¹⁺⁾*2BF₄^(1-)*H⁽¹⁺⁾

: 106502-50-5
3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: In N,N-dimethyl-formamide; for 0.166667h;
DOI:10.1021/jo00381a047

Reference yield:

: 106502-50-5
3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

: 94189-78-3
Dithiophosphoric acid O-[(2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: mesitylenedisulfonyl chloride (MDS) / 0.17 h

2: 0.2 M dichloroacetic acid / CH₂Cl₂ / 0.01 h / 22 °C

With dichloro-acetic acid; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; In dichloromethane;
DOI:10.1021/jo00381a047

Reference yield:

: 106502-50-5
3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

: 106521-95-3
C₇₂H₆₅N₆O₁₆PS

Guidance literature:: Multi-step reaction with 4 steps

1: mesitylenedisulfonyl chloride (MDS) / 0.17 h

2: 100 percent / phosphinic acid (PSA), pyridine / 0.17 h

3: isodurenedisulfonyl chloride (DDS) / pyridine / 0.08 h

4: 100 percent / (i-Pr)2NEt / pyridine / 0.01 h

With pyridine; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; hypophosphorous acid; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; N-ethyl-N,N-diisopropylamine; In pyridine;
DOI:10.1021/jo00381a047