94189-78-3

Upstream product

• 102573-69-3 5'-O-(4-4'-dimethoxytrityl)-N³-benzoyl thymidine 
• 50-89-5 thymidine 
• 80585-43-9 Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 
• 146952-74-1 5'-O-triethylsilylthymidine 
• 106502-50-5 3-Benzoyl-1-{(2R,4S,5R)-4-hydroxy-5-[(3-imidazol-1-ylmethyl-phenyl)-bis-(4-methoxy-phenyl)-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 94219-34-8 Dithiophosphoric acid O-{(2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester 

Downstream Products

• 94219-35-9 C₇₃H₆₇N₅O₁₆P₂S₃ 
• 94189-83-0 C₇₃H₆₆N₄O₁₆P₂S₃ 

Relevant academic research and scientific papers

3-(Imidazol-1-ylmethyl)-4',4''-dimethoxytrityl: A New Functionalized 5'-Hydroxyl Protecting Group Capable of Rapid Internucleotidic Bond Formation in the Phosphorothio Ester Approach

A remarkable rate enhancement of internucleotidic bond formation in DNA synthesis has been achieved by use of 3-(imidazol-1-ylmethyl)-4',4''-dimethoxytrityl as a new 5'-hydroxyl protecting group which has a potential catalytic site for condensation.

A NEW CLASS OF CONDENSING REAGENTS FOR RAPID INTERNUCLEOTIDE BOND FORMATION IN THE PHOSPHOTRIESTER APPROACH AND PREPARATION OF N3-BENZOYLTHYMIDINE AS A KEY INTERMEDIATE IN OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS

Rapid internucleotide bond formation in the phosphotriester approach has been achieved in high yield by use of bis(2,4,6-trihalophenyl)phosphorochloridates (TCP and TBP) as new condensing reagents and the benzoyl group as the N3-imide protecting group of thymidine.