2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Base Information

Chemical Name:2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
CAS No.:1421244-88-3
Molecular Formula:C₅₀H₇₀N₆O₁₃
Molecular Weight:963.138
Hs Code.:

2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Chemical Property of 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Technology Process of 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

There total 6 articles about 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 1421244-88-3
2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1,4-dioxane / 26 h / 20 - 40 °C

2: caesium carbonate / acetonitrile / 25 h / 20 - 65 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C

6: caesium carbonate / acetonitrile / 20 - 60 °C

7: caesium carbonate / acetonitrile / 20 h / 20 °C

8: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With caesium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201202925

Reference yield:

: 1421244-83-8
4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

: 1421244-88-3
2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 20 - 60 °C

2: caesium carbonate / acetonitrile / 20 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With caesium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1002/chem.201202925

Reference yield:

: 1421244-77-0
tert-butyl 16-(4-((4-benzophenyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

: 1421244-88-3
2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: caesium carbonate / acetonitrile / 20 - 60 °C

4: caesium carbonate / acetonitrile / 20 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With caesium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1002/chem.201202925