3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid

Base Information

• Chemical Name: 3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid
• CAS No.: 1204424-02-1
• Molecular Formula: C₁₃H₁₁F₂NO₃S
• Molecular Weight: 299.298
• Mol file: 1204424-02-1.mol

Synonyms:

Chemical Property of 3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid

There total 5 articles about 3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → 3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid (1204424-02-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide; water / 3 h / 100 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

2.2: 0 °C

3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

5.1: copper / dimethyl sulfoxide / 0.5 h / 20 °C

5.2: 0.25 h

6.1: sodium hydroxide; water / ethanol / 0.25 h / 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; water; copper; sodium carbonate; triphenylphosphine; sodium hydroxide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

2-(4-methoxyphenyl)-1,3-thiazole (27088-84-2) → 3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid (1204424-02-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

1.2: 0 °C

2.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

4.1: copper / dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 0.25 h

5.1: sodium hydroxide; water / ethanol / 0.25 h / 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; water; copper; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide;

Reference yield:

5-Hydroxymethyl-2-(4-methoxyphenyl)-thiazole (937668-37-6) → 3-[2-(4-Methoxyphenyl)thiazol-5-yl]-2,2-difluoropropionic acid (1204424-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

2.1: copper / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 0.25 h

3.1: sodium hydroxide; water / ethanol / 0.25 h / 20 °C

With carbon tetrabromide; water; copper; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

4-methoxyphenylboronic acid

2-(4-methoxyphenyl)-1,3-thiazole

5-Hydroxymethyl-2-(4-methoxyphenyl)-thiazole

5-Bromomethyl-2-(4-methoxyphenyl)-thiazole

Refernces