Technology Process of (S)-(4-chlorophenyl)(3-((3-(oxiran-2-yl)benzyl)oxy)phenyl)methanone
There total 6 articles about (S)-(4-chlorophenyl)(3-((3-(oxiran-2-yl)benzyl)oxy)phenyl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium peroxymonosulfate; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate / acetonitrile / 8 h / 0 °C
2: (R,R)-Jacobsen catalyst / Resolution of racemate
With
potassium peroxymonosulfate; (R,R)-Jacobsen catalyst; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate;
In
acetonitrile;
DOI:10.1021/jm201608g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen bromide; acetic acid / water / 36 h / 125 °C
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C
3: potassium peroxymonosulfate; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate / acetonitrile / 8 h / 0 °C
4: (R,R)-Jacobsen catalyst / Resolution of racemate
With
potassium peroxymonosulfate; (R,R)-Jacobsen catalyst; 1,1,1-trifluoro-2-propanone; di-isopropyl azodicarboxylate; hydrogen bromide; edetate disodium; sodium hydrogencarbonate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm201608g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C
1.2: 3.5 h / -78 - 0 °C
2.1: hydrogen bromide; acetic acid / water / 36 h / 125 °C
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C
4.1: potassium peroxymonosulfate; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate / acetonitrile / 8 h / 0 °C
5.1: (R,R)-Jacobsen catalyst / Resolution of racemate
With
potassium peroxymonosulfate; (R,R)-Jacobsen catalyst; 1,1,1-trifluoro-2-propanone; di-isopropyl azodicarboxylate; hydrogen bromide; isopropylmagnesium chloride; edetate disodium; sodium hydrogencarbonate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm201608g
