Technology Process of 6-Iodo-cinnolin-4-ol
There total 2 articles about 6-Iodo-cinnolin-4-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; sodium nitrite;
In
tetrahydrofuran; water;
at 0 ℃;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride; Iodine monochloride / water / 2 h / 0 °C / Cooling with ice
2: hydrogenchloride; sodium nitrite / water; tetrahydrofuran / 3 h / 0 °C / Reflux
With
hydrogenchloride; Iodine monochloride; sodium nitrite;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C
2: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 24 h / 50 °C / Inert atmosphere
3: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 50 °C
4: trichlorophosphate / acetonitrile / 2 h / 100 °C
5: triethylamine / 100 °C
6: trifluoroacetic acid / dichloromethane / 20 °C
7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 40 °C
With
potassium fluoride; copper(l) iodide; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; trichlorophosphate;
palladium 10% on activated carbon;
In
1-methyl-pyrrolidin-2-one; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;