857560-57-7

Basic information

• Product Name: 1-(2-AMino-5-iodo-phenyl)-ethanone
• Synonyms: 1-(2-AMino-5-iodo-phenyl)-ethanone
• CAS NO: 857560-57-7
• Molecular Formula: C₈H₈INO
• Molecular Weight: 261.05969
• EINECS: -0
• Mol File: 857560-57-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-AMino-5-iodo-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-AMino-5-iodo-phenyl)-ethanone(857560-57-7)
• EPA Substance Registry System: 1-(2-AMino-5-iodo-phenyl)-ethanone(857560-57-7)

Safety Data

• Hazardous Substances Data: 857560-57-7(Hazardous Substances Data)

Usage

General Description

1-(2-Amino-5-iodo-phenyl)-ethanone is a chemical compound with the molecular formula C8H8INO. It is also known as 5-Iodo-2-aminoacetophenone and is a derivative of acetophenone. 1-(2-AMino-5-iodo-phenyl)-ethanone contains a benzene ring with an amino group and an iodine atom, as well as a ketone functional group. It is widely used in organic synthesis and pharmaceutical research. Its properties and uses include its role as a building block in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Additionally, it has potential applications in the field of medicinal chemistry, as it exhibits certain biological activities that make it a valuable compound in drug discovery and development.

Upstream product

• 917-54-4 methyllithium 
• 5326-47-6 2-amino-5-iodobenzoic acid 
• 935292-42-5 1,1-dimethylethyl (2-acetyl-4-iodophenyl)carbamate 
• 551-93-9 2-aminoacetophenone 

Downstream Products

• 1610538-71-0 2,5-diiodoacetophenone 
• 1352935-10-4 4-(benzyloxy)-6-(trifluoromethyl)cinnoline 
• 1352935-09-1 4-(benzyloxy)-6-iodocinnoline 
• 854892-08-3 6-iodocinnolin-4-ol 

Relevant articles and documents

An unexpected synthesis and application of ethyl 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate

An unexpected and direct synthesis of ethyl 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate (3) from the chlorotrimethylsilane (TMSCl)-promoted Friedl?nder reaction between 1-(2-amino-5-iodophenyl)ethanone (2) and ethyl 4-chloro-3-oxobutanoate has bee

A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines

We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO2CF3 groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups.

Synthesis of 3-Substituted 2,1-Benzisoxazoles by the Oxidative Cyclization of 2-Aminoacylbenzenes with Oxone

An efficient approach to the synthesis of 2,1-benzisoxazoles through direct construction of the N-O bond by the chemoselective oxidation of 2-aminoacylbenzenes with Oxone is described. This alternative methodology is characterized by its simple and transition-metal-free conditions and good functional group compatibility utilizing Oxone as a green oxidant instead of hypervalent iodine compounds. Moreover, this new procedure simplifies the number of steps compared to the previously reported procedure by circumventing the use of 2-azido-substituted aryl ketones.