2-(4-FLUOROPHENYL)ACETOPHENONE

Base Information

• Chemical Name: 2-(4-FLUOROPHENYL)ACETOPHENONE
• CAS No.: 347-91-1
• Molecular Formula: C14H11 F O
• Molecular Weight: 214.239
• Hs Code.: 2914700090
• Mol file: 347-91-1.mol

Synonyms:Acetophenone,2-(p-fluorophenyl)- (6CI,7CI); 2-(4-Fluorophenyl)-1-phenylethanone;4-Fluorobenzyl phenyl ketone; NSC 38740; p-Fluorobenzyl phenyl ketone

Chemical Property of 2-(4-FLUOROPHENYL)ACETOPHENONE

Chemical Property:

• Vapor Pressure: 0.000224mmHg at 25°C
• Melting Point: 86 °C
• Boiling Point: 325.9°Cat760mmHg
• Flash Point: 134.6°C
• PSA: 17.07000
• Density: 1.152g/cm³
• LogP: 3.25110
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Fluorophenyl)-1-phenylethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUOROPHENYL)ACETOPHENONE

There total 46 articles about 2-(4-FLUOROPHENYL)ACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) + 4-Fluorophenylacetyl chloride (459-04-1) → 2-(4-fluorophenyl)-1-phenylethanone (347-91-1)

Guidance literature:

With aluminium trichloride; at 50 ℃; for 8h;

DOI:10.1016/j.tet.2007.06.005

Reference yield: 94.8%

4-Fluorobenzyl bromide (459-46-1) → 2-(4-fluorophenyl)-1-phenylethanone (347-91-1)

Guidance literature:

With magnesium; In benzonitrile;

Reference yield: 92.0%

C9H9FO (121039-99-4) + benzenediazonium tetrafluoroborate (369-57-3) → 2-(4-fluorophenyl)-1-phenylethanone (347-91-1)

Guidance literature:

With palladium diacetate; In tetrahydrofuran; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1039/d1ob01503f

upstream raw materials:

benzoyl chloride

1-chloromethyl-4-fluorobenzene

1-chloroacetophenone

1-Bromo-4-fluorobenzene

Downstream raw materials:

2-(4-Fluorphenyl)-1-phenyl-1-ethanon-p-tolylsulfonylhydrazon

2-(4-fluorophenyl)-1-phenyl-2-p-tolylethanone

2-(4-Fluoro-phenyl)-2-{[1-(4-fluoro-phenyl)-2-oxo-2-phenyl-eth-(E)-ylidene]-hydrazono}-1-phenyl-ethanone

Benzoyl-p-fluor-phenyl-diazomethan

Refernces

• 1、 Xie, Shaolei,He, Zhi-Juan,Zhang, Ling-Hui,Huang, Bo-Lun,Chen, Xiao-Wei,Zhan, Zong-Song,Zhang, Fu-Min. "The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters". supporting information. p. 2069 - 2072. Retrieved 2021/03/01.
• 2、 Bouquin, Maxime,Jaroschik, Florian,Taillefer, Marc. "Versatile and base-free copper-catalyzed α-arylations of aromatic ketones using diaryliodonium salts". supporting information. . Retrieved 2021/06/11.