(S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride

Base Information

• Chemical Name: (S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride
• CAS No.: 367261-25-4
• Molecular Formula: C₂₆H₂₁Cl₃N₂O₃
• Molecular Weight: 515.823
• Mol file: 367261-25-4.mol

Synonyms:

Chemical Property of (S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride

There total 2 articles about (S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S)-4-[(4R)-7-cyano-4-methyl-1-oxo-1,3,4,6-tetrahydro-2H-naphtho[1,2-f][1,4]oxazocin-2-yl]-3-(3,4-dichlorophenyl)butanoic acid (367261-23-2) → (S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride (367261-25-4)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.5h;

DOI:10.1016/j.tet.2004.03.054

Reference yield:

11-[2-(3,4-dichloro-phenyl)-4-oxo-butyl]-9-methyl-12-oxo-9,10,11,12-tetrahydro-7H-8-oxa-11-aza-cycloocta[a]naphthalene-6-carbonitrile (367261-21-0) → (S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride (367261-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Jones reagent / acetone; propan-2-ol / 0 °C

2: oxalyl chloride; dimethylformamide / CH₂Cl₂ / 0.5 h

With jones reagent; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; isopropyl alcohol; acetone;

DOI:10.1016/j.tet.2004.03.054

Reference yield:

dimethyl amine (124-40-3) + (S)-4-((R)-6-Cyano-9-methyl-12-oxo-7,9,10,12-tetrahydro-8-oxa-11-aza-cycloocta[a]naphthalen-11-yl)-3-(3,4-dichloro-phenyl)-butyryl chloride (367261-25-4) → (3S)-4-[(4R)-7-cyano-4-methyl-1-oxo-1,3,4,6-tetrahydro-2H-naphtho[1,2-f][1,4]oxazocin-2-yl]-3-(3,4-dichlorophenyl)-N,N-dimethylbutanamide

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane; for 0.25h;

DOI:10.1016/j.tet.2004.03.054

upstream raw materials:

(3S)-4-[(4R)-7-cyano-4-methyl-1-oxo-1,3,4,6-tetrahydro-2H-naphtho[1,2-f][1,4]oxazocin-2-yl]-3-(3,4-dichlorophenyl)butanoic acid

11-[2-(3,4-dichloro-phenyl)-4-oxo-butyl]-9-methyl-12-oxo-9,10,11,12-tetrahydro-7H-8-oxa-11-aza-cycloocta[a]naphthalene-6-carbonitrile