2-Chloro-1-(2-chloro-4,5-difluorophenyl)ethan-1-one

Base Information

Chemical Name:2-Chloro-1-(2-chloro-4,5-difluorophenyl)ethan-1-one
CAS No.:133117-00-7
Molecular Formula:C8H4Cl2F2O
Molecular Weight:225.022
Hs Code.:
DSSTox Substance ID:DTXSID10564380
Wikidata:Q82449073

Synonyms:133117-00-7;2-Chloro-1-(2-chloro-4,5-difluorophenyl)ethan-1-one;SCHEMBL9516561;DTXSID10564380;2'-Chloro-4',5'-difluorophenacyl chloride;EN300-1965529

Suppliers and Price of 2-Chloro-1-(2-chloro-4,5-difluorophenyl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Chloro-1-(2-chloro-4,5-difluorophenyl)ethan-1-one

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:223.9607265
Heavy Atom Count:13
Complexity:201

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1F)F)Cl)C(=O)CCl

Technology Process of 2-Chloro-1-(2-chloro-4,5-difluorophenyl)ethan-1-one

There total 6 articles about 2-Chloro-1-(2-chloro-4,5-difluorophenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 696-02-6
4-chloro-1,2-difluorobenzene

: 79-04-9
chloroacetyl chloride

: 133117-00-7
2-chloro-4,5-difluoro-α-chloroacetophenone

Guidance literature:: With aluminium trichloride;

Reference yield:

: 345-18-6
2-fluoro-5-chloronitrobenzene

: 133117-00-7
2-chloro-4,5-difluoro-α-chloroacetophenone

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr

2: BF₃*Et₂O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C

3: 49 percent / 0.5 h / 170 °C

4: 95 percent / AlCl₃

With aluminium trichloride; tert.-butylnitrite; boron trifluoride diethyl etherate; hydrogen; platinum on activated charcoal; In 1,2-dimethoxyethane; 1: Catalytic hydrogenation / 2: Diazotization / 3: Decomposition / 4: Acylation;

Reference yield:

: 2106-05-0
5-chloro-2-fluoroaniline

: 133117-00-7
2-chloro-4,5-difluoro-α-chloroacetophenone

Guidance literature:: Multi-step reaction with 3 steps

1: BF₃*Et₂O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C

2: 49 percent / 0.5 h / 170 °C

3: 95 percent / AlCl₃

With aluminium trichloride; tert.-butylnitrite; boron trifluoride diethyl etherate; In 1,2-dimethoxyethane; 1: Diazotization / 2: Decomposition / 3: Acylation;