N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide

Base Information

• Chemical Name: N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide
• CAS No.: 1448309-57-6
• Molecular Formula: C₂₈H₂₅ClF₂N₄O₃
• Molecular Weight: 538.981
• Mol file: 1448309-57-6.mol

Synonyms:

Chemical Property of N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide

There total 5 articles about N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.8%

pyridyl-3-yl-acetic acid (501-81-5) + 3,3-difluoroisocyanobutane + 2-chloro-benzaldehyde (89-98-5) + Ν-(3-aminophenyl)prop-2-enamide (16230-24-3) → N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide (1448309-57-6)

Guidance literature:

Reference yield:

3-nitro-aniline (99-09-2) → N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide (1448309-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: tin(ll) chloride / ethanol / 20 °C

With triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; 3: |Ugi Condensation;

Reference yield:

Ν-(3-nitrophenyl)acrylamide (17090-15-2) → N-(3-(N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-2-(pyridin-3-yl)acetamido)phenyl)acrylamide (1448309-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(ll) chloride / ethanol / 20 °C

With tin(ll) chloride; In ethanol; 2: |Ugi Condensation;

upstream raw materials:

N-(3,3-difluorocyclobutyl)formamide

3-nitro-aniline

Ν-(3-nitrophenyl)acrylamide

pyridyl-3-yl-acetic acid