C₁₇H₁₆F₂N₄O₂S

Base Information

• Chemical Name: C₁₇H₁₆F₂N₄O₂S
• CAS No.: 1451996-23-8
• Molecular Formula: C₁₇H₁₆F₂N₄O₂S
• Molecular Weight: 378.402
• Mol file: 1451996-23-8.mol

Synonyms:

Chemical Property of C₁₇H₁₆F₂N₄O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₇H₁₆F₂N₄O₂S

There total 3 articles about C₁₇H₁₆F₂N₄O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylate (1451998-17-6) + 3,5-Difluoro-4-methoxybenzylamine (105969-16-2) → C17H16F2N4O2S (1451996-23-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.6b00461

Reference yield:

3-chloro-5,6-dimethylpyridazine-4-carbonitrile (93824-72-7) → C17H16F2N4O2S (1451996-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.6b00461

Reference yield:

→ C17H16F2N4O2S (1451996-23-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

3-chloro-5,6-dimethylpyridazine-4-carbonitrile

sodium 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylate

3,5-Difluoro-4-methoxybenzylamine