C₁₅H₁₈F₃NO₂

Base Information

• Chemical Name: C₁₅H₁₈F₃NO₂
• CAS No.: 1227566-37-1
• Molecular Formula: C₁₅H₁₈F₃NO₂
• Molecular Weight: 301.309
• Mol file: 1227566-37-1.mol

Synonyms:

Chemical Property of C₁₅H₁₈F₃NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₈F₃NO₂

There total 4 articles about C₁₅H₁₈F₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (954236-44-3) → C15H18F3NO2 (1227566-37-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 0 °C

2: carbon tetrabromide; triphenylphosphine / tetrahydrofuran

3: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

4: hydrogenchloride / 1,4-dioxane; dichloromethane

With nickel(II) iodide; hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol; 3: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.08.048

Reference yield:

tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate (240401-09-6) → C15H18F3NO2 (1227566-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran

2: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

3: hydrogenchloride / 1,4-dioxane; dichloromethane

With nickel(II) iodide; hydrogenchloride; carbon tetrabromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.08.048

Reference yield:

tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (898157-46-5) → C15H18F3NO2 (1227566-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

2: hydrogenchloride / 1,4-dioxane; dichloromethane

With nickel(II) iodide; hydrogenchloride; lithium hexamethyldisilazane; In 1,4-dioxane; dichloromethane; isopropyl alcohol; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.08.048

upstream raw materials:

tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate

tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate