N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide

Base Information

• Chemical Name: N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide
• CAS No.: 1307271-72-2
• Molecular Formula: C₂₀H₂₂F₂N₆O₃S₂
• Molecular Weight: 496.562
• Mol file: 1307271-72-2.mol

Synonyms:

Chemical Property of N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide

There total 3 articles about N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-methylpyrimidine (13036-57-2) → N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide (1307271-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -10 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / Inert atmosphere

2.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 60 °C / Inert atmosphere

3.1: ammonia / isopropyl alcohol / 85 - 100 °C / Inert atmosphere

With N-Bromosuccinimide; ammonia; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE; isopropyl alcohol;

Reference yield:

methyl 2,6-difluoro-3-(propylsulfonamido)benzoate (1186223-50-6) → N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide (1307271-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -10 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / Inert atmosphere

2.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 0.5 h / 0 °C / Inert atmosphere

2.2: 4 h / 60 °C / Inert atmosphere

3.1: ammonia / isopropyl alcohol / 85 - 100 °C / Inert atmosphere

With N-Bromosuccinimide; ammonia; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE; isopropyl alcohol;

Reference yield:

N-{3-[(2-chloro-4-pyrimidinyl)acetyl]-2,4-difluorophenyl}-1-propanesulfonamide (1307272-50-9) → N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-1-propanesulfonamide (1307271-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 60 °C / Inert atmosphere

2.1: ammonia / isopropyl alcohol / 85 - 100 °C / Inert atmosphere

With N-Bromosuccinimide; ammonia; In ISOPROPYLAMIDE; isopropyl alcohol;

upstream raw materials:

2-chloro-4-methylpyrimidine

methyl 2,6-difluoro-3-(propylsulfonamido)benzoate

N-{3-[(2-chloro-4-pyrimidinyl)acetyl]-2,4-difluorophenyl}-1-propanesulfonamide