((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)

Base Information

Chemical Name:((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)
CAS No.:1624289-51-5
Molecular Formula:C₃₀H₃₇N₅O₂
Molecular Weight:499.656
Hs Code.:

((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)

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Chemical Property of ((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)

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Technology Process of ((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)

There total 8 articles about ((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1624289-38-8
((4aR,8R,9aR)-1-(2-(dimethylamino)ethyl)-1,4,4a,6,7,8,9,9a-octahydroindolo[1,14-fg]quinolin-8-yl)(pyrrolidin-1-yl)methanone

: 103-71-9
phenyl isocyanate

: 1624289-51-5
((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)

Guidance literature:: In dichloromethane; at 20 ℃; for 12h;
DOI:10.1002/cmdc.201402055

Reference yield:

: 1624289-35-5
isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

: 1624289-51-5
((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C

3: acetonitrile / 50 °C / Inert atmosphere; Sealed tube

4: dichloromethane / 12 h / 20 °C

With lithium borohydride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201402055

Reference yield:

: 1646866-97-8
C₂₂H₂₁N₃O₃

: 1624289-51-5
((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)carboxamide)

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

2: sodium hydroxide; tetra-(n-butyl)ammonium iodide / dichloromethane / 0 - 20 °C

3: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 4 h / 0 - 20 °C

5: acetonitrile / 50 °C / Inert atmosphere; Sealed tube

6: dichloromethane / 12 h / 20 °C

With lithium borohydride; tetra-(n-butyl)ammonium iodide; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201402055