isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

Base Information

Chemical Name:isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate
CAS No.:1624289-35-5
Molecular Formula:C₃₁H₃₆N₄O₄
Molecular Weight:528.651
Hs Code.:

Synonyms:isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

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Chemical Property of isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

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Technology Process of isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

There total 5 articles about isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 29921-57-1
isopropyl 2-bromoacetate

: 1624289-34-4
(4aR,8R,9aR)-N-phenyl-8-(pyrrolidine-1-carbonyl)-4,4a,7,8,9,9ahexahydroindolo[1,14-fg]quinoline-6(1H)-carboxamide

: 1624289-35-5
isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydroxide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/cmdc.201402055

Reference yield:

: 103-71-9
phenyl isocyanate

: 1624289-35-5
isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 20 °C

2: sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

4: sodium hydroxide; tetra-(n-butyl)ammonium iodide / dichloromethane / 0 - 20 °C

With tetra-(n-butyl)ammonium iodide; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/cmdc.201402055

Reference yield:

: 1646866-97-8
C₂₂H₂₁N₃O₃

: 1624289-35-5
isopropyl 2-((4aR,8R,9aR)-6-(phenylcarbamoyl)-8-(pyrrolidine-1-carbonyl)-4a,6,7,8,9,9a-hexahydroindolo[1,14-fg]quinolin-1(4H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

2: sodium hydroxide; tetra-(n-butyl)ammonium iodide / dichloromethane / 0 - 20 °C

With tetra-(n-butyl)ammonium iodide; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In dichloromethane;
DOI:10.1002/cmdc.201402055