Tetrahydrofuran-2,5-diol

Base Information

• Chemical Name: Tetrahydrofuran-2,5-diol
• CAS No.: 133200-67-6
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• DSSTox Substance ID: DTXSID50400177
• Nikkaji Number: J2.269.623H
• Mol file: 133200-67-6.mol

Synonyms:Tetrahydrofuran-2,5-diol;133200-67-6;2,5-Furandiol, tetrahydro-;2,5-tetrahydrofurandiol;SCHEMBL692856;2,5-dihydroxy-2,4-dihydrofuran;DTXSID50400177;AKOS024432717

Chemical Property of Tetrahydrofuran-2,5-diol

Chemical Property:

• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 104.047344113
• Heavy Atom Count: 7
• Complexity: 56

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(OC1O)O

Technology Process of Tetrahydrofuran-2,5-diol

There total 1 articles about Tetrahydrofuran-2,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) → 2,5-dihydroxy-tetrahydrofuran (133200-67-6)

Guidance literature:

In water-d2; for 2h; Heating;

DOI:10.1016/j.tetlet.2005.11.104

Reference yield: 71.0%

2,5-dihydroxy-tetrahydrofuran (133200-67-6) + 2-amino-5-bromo-4-methylpyridine (98198-48-2) → C10H9BrN2 (858523-53-2)

Guidance literature:

With acetic acid; at 90 ℃; for 2h;

Reference yield:

2,5-dihydroxy-tetrahydrofuran (133200-67-6) + acetonedicarboxylic acid (542-05-2) + benzylamine (100-46-9) → N-benzyltropinone (28957-72-4)

Guidance literature:

2,5-dihydroxy-tetrahydrofuran; acetonedicarboxylic acid; benzylamine; With sodium hydroxide; sodium dihydrogenphosphate; pH=4.5;

With hydrogenchloride; at 85 ℃; for 2h; pH=3;

With sodium hydroxide; di-tert-butyl dicarbonate; more than 3 stages;

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

Downstream raw materials:

C₁₀H₉BrN₂

N-benzyltropinone