<1S-(1R^*,2S^*,3R^*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester

Base Information

• Chemical Name: <1S-(1R^*,2S^*,3R^*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester
• CAS No.: 134335-01-6
• Molecular Formula: C₃₃H₅₂N₄O₉S
• Molecular Weight: 680.863

Synonyms:

Chemical Property of <1S-(1R^*,2S^*,3R^*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1S-(1R^*,2S^*,3R^*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester

There total 5 articles about <1S-(1R^*,2S^*,3R^*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

<1S-(1R*,2S*,3R*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine (127953-25-7,134452-01-0,134452-02-1) + allyl alcohol (107-18-6) → <1S-(1R*,2S*,3R*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester (134335-01-6,134452-09-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In diethyl ether; Ambient temperature;

DOI:10.1021/jm00111a002

Reference yield:

N-(4-MorpholinYlsulfonyl)-L-phenylalanine (124278-39-3) → <1S-(1R*,2S*,3R*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester (134335-01-6,134452-09-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 67 percent / dicyclohexylcarbodiimide, HOBT, triethylamine / CH₂Cl₂; dimethylformamide

2: 97.4 percent / H₂ / 20percent Pd/C / methanol / 2 h

3: 52 percent / HOBT, triethylamine, dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 1.) 0 deg C - RT, 2.) RT, overnight

4: 83 percent / 1N aq. NaOH / methanol / Ambient temperature

5: 88 percent / dicyclohexylcarbodiimide / diethyl ether / Ambient temperature

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00111a002

Reference yield:

2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-malonic acid benzyl ester methyl ester (127953-31-5) → <1S-(1R*,2S*,3R*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester (134335-01-6,134452-09-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 97.4 percent / H₂ / 20percent Pd/C / methanol / 2 h

2: 52 percent / HOBT, triethylamine, dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 1.) 0 deg C - RT, 2.) RT, overnight

3: 83 percent / 1N aq. NaOH / methanol / Ambient temperature

4: 88 percent / dicyclohexylcarbodiimide / diethyl ether / Ambient temperature

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00111a002

upstream raw materials:

<1S-(1R^*,2S^*,3R^*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine

allyl alcohol

N-(4-MorpholinYlsulfonyl)-L-phenylalanine

N-(4-morpholinylsulfonyl)-L-phenylalanyl-DL-2-(methoxycarbonyl)glycine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 134335-01-6 <1S-(1R^*,2S^*,3R^*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N--3-oxo-DL-alanine allyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send