Ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

Base Information

Chemical Name:Ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate
CAS No.:133619-67-7
Molecular Formula:C24H19NO3
Molecular Weight:369.42
Hs Code.:
DSSTox Substance ID:DTXSID70565313
Nikkaji Number:J2.221.640F
Wikidata:Q82450348

Synonyms:DTXSID70565313;Ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

Suppliers and Price of Ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:369.13649347
Heavy Atom Count:28
Complexity:550

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(C(=C2N1C=CC=C2)C(=O)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of Ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

There total 3 articles about Ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 17282-40-5
N-(ethoxycarbonylmethyl)pyridinium bromide

: 7338-94-5
1,3-diphenyl-2-propynone

: 133619-67-7
ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; Ambient temperature;

Reference yield: 55.0%

: 17282-40-5
N-(ethoxycarbonylmethyl)pyridinium bromide

: 98-88-4
benzoyl chloride

: 536-74-3
phenylacetylene

: 133619-67-7
ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

Guidance literature:: benzoyl chloride; phenylacetylene; With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 2h;

N-(ethoxycarbonylmethyl)pyridinium bromide; In tetrahydrofuran; at 20 ℃; for 14h;
DOI:10.1002/hlca.200590141

Reference yield:

: 110-86-1
pyridine

: 133619-67-7
ethyl 1-benzoyl-2-phenylindolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetone / 3 h / 20 °C

2.1: CuI; Et₃N / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 2 h / 20 °C

2.2: 55 percent / tetrahydrofuran / 14 h / 20 °C

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetone; 2.1: Sonogashira coupling reaction;
DOI:10.1002/hlca.200590141