Technology Process of 10-Thia-5-deazafolic acid
There total 9 articles about 10-Thia-5-deazafolic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium borohydride / ethanol / 0.17 h / Ambient temperature
2: 78 percent / N,N-dimethyl-acetamide / 74 h / Ambient temperature
3: 81 percent / 1 N sodium hydroxide / ethanol; H2O / 60 h / Ambient temperature
4: 1.) triethylamine, diethyl phosphorocyanidate / 1.) DMF, r.t., 1.5 h, 2.) r.t., then 65 deg C, 2 h
5: 77 percent / trifluoroacetic acid / 3 h / Ambient temperature
With
sodium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; triethylamine; trifluoroacetic acid;
In
ethanol; N,N-dimethyl acetamide; water;
DOI:10.1002/jhet.5570280423
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / NaBH4 / 2-methoxy-ethanol / Ambient temperature
2: 100 percent / 1 N sodium hydroxide / 6 h / Heating
3: 96 percent / phosphorus tribromide / tetrahydrofuran
4: 78 percent / N,N-dimethyl-acetamide / 74 h / Ambient temperature
5: 81 percent / 1 N sodium hydroxide / ethanol; H2O / 60 h / Ambient temperature
6: 1.) triethylamine, diethyl phosphorocyanidate / 1.) DMF, r.t., 1.5 h, 2.) r.t., then 65 deg C, 2 h
7: 77 percent / trifluoroacetic acid / 3 h / Ambient temperature
With
sodium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; phosphorus tribromide; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; 2-methoxy-ethanol; N,N-dimethyl acetamide; water;
DOI:10.1002/jhet.5570280423
