Di-tert-butyl 10-thia-5-deazafolate

Base Information

Chemical Name:Di-tert-butyl 10-thia-5-deazafolate
CAS No.:136649-93-9
Molecular Formula:C₂₈H₃₅N₅O₆S
Molecular Weight:569.682
Hs Code.:

Synonyms:

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Chemical Property of Di-tert-butyl 10-thia-5-deazafolate

Chemical Property:

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Technology Process of Di-tert-butyl 10-thia-5-deazafolate

There total 8 articles about Di-tert-butyl 10-thia-5-deazafolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20057-83-4
diethyl 4,4'-dithiobis

: 136649-93-9
Di-tert-butyl 10-thia-5-deazafolate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium borohydride / ethanol / 0.17 h / Ambient temperature

2: 78 percent / N,N-dimethyl-acetamide / 74 h / Ambient temperature

3: 81 percent / 1 N sodium hydroxide / ethanol; H₂O / 60 h / Ambient temperature

4: 1.) triethylamine, diethyl phosphorocyanidate / 1.) DMF, r.t., 1.5 h, 2.) r.t., then 65 deg C, 2 h

With sodium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; triethylamine; In ethanol; N,N-dimethyl acetamide; water;
DOI:10.1002/jhet.5570280423

Reference yield:

: 80360-04-9
2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine

: 136649-93-9
Di-tert-butyl 10-thia-5-deazafolate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / NaBH₄ / 2-methoxy-ethanol / Ambient temperature

2: 100 percent / 1 N sodium hydroxide / 6 h / Heating

3: 96 percent / phosphorus tribromide / tetrahydrofuran

4: 78 percent / N,N-dimethyl-acetamide / 74 h / Ambient temperature

5: 81 percent / 1 N sodium hydroxide / ethanol; H₂O / 60 h / Ambient temperature

6: 1.) triethylamine, diethyl phosphorocyanidate / 1.) DMF, r.t., 1.5 h, 2.) r.t., then 65 deg C, 2 h

With sodium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; phosphorus tribromide; triethylamine; In tetrahydrofuran; ethanol; 2-methoxy-ethanol; N,N-dimethyl acetamide; water;
DOI:10.1002/jhet.5570280423

Reference yield:

: 87171-09-3
2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine

: 136649-93-9
Di-tert-butyl 10-thia-5-deazafolate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 1 N sodium hydroxide / 6 h / Heating

2: 96 percent / phosphorus tribromide / tetrahydrofuran

3: 78 percent / N,N-dimethyl-acetamide / 74 h / Ambient temperature

4: 81 percent / 1 N sodium hydroxide / ethanol; H₂O / 60 h / Ambient temperature

5: 1.) triethylamine, diethyl phosphorocyanidate / 1.) DMF, r.t., 1.5 h, 2.) r.t., then 65 deg C, 2 h

With sodium hydroxide; diethyl cyanophosphonate; phosphorus tribromide; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water;
DOI:10.1002/jhet.5570280423