(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene

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Chemical Name:(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene
CAS No.:194158-64-0
Molecular Formula:C₄₇H₇₈O₄Si₂
Molecular Weight:763.305
Hs Code.:

(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene

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Chemical Property of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene

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Technology Process of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene

There total 7 articles about (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-59-4
phenylmagnesium chloride

: 194158-64-0
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CuCN, LiCl / 1) THF, -78 deg C; 2) THF, -78 deg C, 6 h, -78 deg C --> rt, 12 h

2: tetrabutylammonium fluoride / tetrahydrofuran / 1) rt, 8 d; 2) 60 deg C, 20 h

3: 98 percent / pyridinium dichromate, pyridinium tosylate / CH₂Cl₂ / 5 h / Ambient temperature

4: 1.) PhLi / 1) cyclohexane, Et₂O, THF, -78 deg C, 10 min; 2) cyclohexane, Et₂O, THF, -78 deg C, 3 h, -65 deg C, 30 min

With dipyridinium dichromate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; phenyllithium; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo970604u

Reference yield:

: 104651-47-0
(S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal

: 194158-64-0
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1) hexane, Et₂O, -78 deg C, 4 h; 2) Et₂O, hexane, -85 deg C, 2 h

2: 1.) n-BuLi / 1) hexane, Et₂O, -78 deg C, 15 min; 2) hexane, Et₂O, 3 h

3: 1.) CuCN, LiCl / 1) THF, -78 deg C; 2) THF, -78 deg C, 6 h, -78 deg C --> rt, 12 h

4: tetrabutylammonium fluoride / tetrahydrofuran / 1) rt, 8 d; 2) 60 deg C, 20 h

5: 98 percent / pyridinium dichromate, pyridinium tosylate / CH₂Cl₂ / 5 h / Ambient temperature

6: 1.) PhLi / 1) cyclohexane, Et₂O, THF, -78 deg C, 10 min; 2) cyclohexane, Et₂O, THF, -78 deg C, 3 h, -65 deg C, 30 min

With dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; phenyllithium; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo970604u

Reference yield:

: Tributyl-((E)-3-methoxymethoxy-3-methyl-but-1-enyl)-stannane

: 194158-64-0
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((E)-(1R,4R)-5-methoxymethoxy-1,5-dimethyl-4-phenyl-hex-2-enyl)-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1) hexane, Et₂O, -78 deg C, 4 h; 2) Et₂O, hexane, -85 deg C, 2 h

2: 1.) n-BuLi / 1) hexane, Et₂O, -78 deg C, 15 min; 2) hexane, Et₂O, 3 h

3: 1.) CuCN, LiCl / 1) THF, -78 deg C; 2) THF, -78 deg C, 6 h, -78 deg C --> rt, 12 h

4: tetrabutylammonium fluoride / tetrahydrofuran / 1) rt, 8 d; 2) 60 deg C, 20 h

5: 98 percent / pyridinium dichromate, pyridinium tosylate / CH₂Cl₂ / 5 h / Ambient temperature

6: 1.) PhLi / 1) cyclohexane, Et₂O, THF, -78 deg C, 10 min; 2) cyclohexane, Et₂O, THF, -78 deg C, 3 h, -65 deg C, 30 min

With dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; phenyllithium; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo970604u