(6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester

Base Information

Chemical Name:(6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester
CAS No.:206854-63-9
Molecular Formula:C₂₅H₂₅ClN₂O₇
Molecular Weight:500.936
Hs Code.:

(6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester

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Chemical Property of (6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester

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Technology Process of (6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester

There total 11 articles about (6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 206854-63-9
(6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: TsOH / CH₂Cl₂

2.1: NaOH / acetone

3.1: POCl₃ / CH₂Cl₂

4.1: pyridine

5.1: HCl / acetone

6.1: 99 percent / AlCl₃; anisole / CH₂Cl₂

7.1: sodium 2-ethylhexanoate / methanol; ethyl acetate

7.2: dimethylformamide

8.1: 47 percent / Mg; acetic acid / CH₂Cl₂

9.1: pyridine / CH₂Cl₂

10.1: Cl₂ / CCl₄ / Irradiation

11.1: aq. NaHCO₃

With pyridine; hydrogenchloride; sodium hydroxide; aluminium trichloride; chlorine; sodium hydrogencarbonate; toluene-4-sulfonic acid; magnesium; acetic acid; methoxybenzene; trichlorophosphate; sodium 2-ethylhexanoic acid; In methanol; tetrachloromethane; dichloromethane; ethyl acetate; acetone; 1.1: Addition / 2.1: Hydrolysis / 3.1: Chlorination / 4.1: Acylation / 5.1: acidolysis / 6.1: dealkylation / 7.1: deprotonation / 7.2: Alkylation / 8.1: Reduction / 9.1: Acylation / 10.1: Chlorination / 11.1: Dehydrochlorination;
DOI:10.1016/S0960-894X(00)00488-1

Reference yield:

: 75007-70-4
decarboxy-moxalactam

: 206854-63-9
(6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium 2-ethylhexanoate / methanol; ethyl acetate

1.2: dimethylformamide

2.1: 47 percent / Mg; acetic acid / CH₂Cl₂

3.1: pyridine / CH₂Cl₂

4.1: Cl₂ / CCl₄ / Irradiation

5.1: aq. NaHCO₃

With pyridine; chlorine; sodium hydrogencarbonate; magnesium; acetic acid; sodium 2-ethylhexanoic acid; In methanol; tetrachloromethane; dichloromethane; ethyl acetate; 1.1: deprotonation / 1.2: Alkylation / 2.1: Reduction / 3.1: Acylation / 4.1: Chlorination / 5.1: Dehydrochlorination;
DOI:10.1016/S0960-894X(00)00488-1

Reference yield:

: 114652-98-1
2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)acetic acid

: 206854-63-9
(6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-acetylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: POCl₃ / CH₂Cl₂

2.1: pyridine

3.1: HCl / acetone

4.1: 99 percent / AlCl₃; anisole / CH₂Cl₂

5.1: sodium 2-ethylhexanoate / methanol; ethyl acetate

5.2: dimethylformamide

6.1: 47 percent / Mg; acetic acid / CH₂Cl₂

7.1: pyridine / CH₂Cl₂

8.1: Cl₂ / CCl₄ / Irradiation

9.1: aq. NaHCO₃

With pyridine; hydrogenchloride; aluminium trichloride; chlorine; sodium hydrogencarbonate; magnesium; acetic acid; methoxybenzene; trichlorophosphate; sodium 2-ethylhexanoic acid; In methanol; tetrachloromethane; dichloromethane; ethyl acetate; acetone; 1.1: Chlorination / 2.1: Acylation / 3.1: acidolysis / 4.1: dealkylation / 5.1: deprotonation / 5.2: Alkylation / 6.1: Reduction / 7.1: Acylation / 8.1: Chlorination / 9.1: Dehydrochlorination;
DOI:10.1016/S0960-894X(00)00488-1