Latamoxef Impurity 1

Base Information

• Chemical Name: Latamoxef Impurity 1
• CAS No.: 75007-70-4
• Molecular Formula: C19H20N6O7S
• Molecular Weight: 476.46
• Mol file: 75007-70-4.mol

Synonyms:(6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;

Chemical Property of Latamoxef Impurity 1

Chemical Property:

• PSA: 194.30000
• LogP: -0.42460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Latamoxef Impurity 1

There total 14 articles about Latamoxef Impurity 1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (315663-45-7) → decarboxy-moxalactam (75007-70-4)

Guidance literature:

With aluminium trichloride; methoxybenzene; In dichloromethane;

DOI:10.1016/S0960-894X(00)00488-1

Reference yield: 82.7%

(6R,7R)-7-[2-(4-Benzyloxycarbonyloxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (86862-88-6) → decarboxy-moxalactam (75007-70-4)

Guidance literature:

With aluminium trichloride; methoxybenzene; at 0 ℃; for 0.5h;

DOI:10.1021/jm00365a006

Reference yield:

4-hydroxyphenylacetate (156-38-7) → decarboxy-moxalactam (75007-70-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 76.3 percent / diethyl ether

2: 84.1 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

3: 98 percent / CF₃COOH, anisole / CH₂Cl₂ / 0.75 h / 0 °C

4: oxalyl chloride, DMF / benzene / 1 h / Ambient temperature

5: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

6: 82.7 percent / AlCl₃, anisole / 0.5 h / 0 °C

With pyridine; aluminium trichloride; oxalyl dichloride; methoxybenzene; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In diethyl ether; dichloromethane; benzene;

DOI:10.1021/jm00365a006

upstream raw materials:

(6R,7R)-7-[2-(4-Benzyloxycarbonyloxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

moxalactam

(6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Methyl 4-hydroxyphenylacetate

Downstream raw materials:

(6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-methyl-benzyl ester