2-Ethyl-4-methoxyphenol

Base Information

• Chemical Name: 2-Ethyl-4-methoxyphenol
• CAS No.: 13391-32-7
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• DSSTox Substance ID: DTXSID00516030
• Nikkaji Number: J2.697.307D
• Wikidata: Q82377245
• Mol file: 13391-32-7.mol

Synonyms:2-ETHYL-4-METHOXYPHENOL;13391-32-7;SCHEMBL805304;DTXSID00516030;MB23776

Chemical Property of 2-Ethyl-4-methoxyphenol

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 114

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(C=CC(=C1)OC)O

Technology Process of 2-Ethyl-4-methoxyphenol

There total 7 articles about 2-Ethyl-4-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(1-hydroxyethyl)-4-methoxyphenol (101231-95-2) → 2-ethyl-4-methoxy-phenol (13391-32-7)

Guidance literature:

With triethylsilane; In trifluoroacetic acid;

DOI:10.1039/c39850001291

Reference yield: 72.0%

triethyl borane (97-94-9) + 2-bromo-4-methoxyphenol (17332-11-5) → 2-ethyl-4-methoxy-phenol (13391-32-7) + 4-methoxy-phenol (150-76-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In tetrahydrofuran; chemoselective reaction; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2009.01.090

Reference yield: 72.0%

triethyl borane (97-94-9) + 2-bromo-4-methoxyphenol (17332-11-5) → 2-ethyl-4-methoxy-phenol (13391-32-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In tetrahydrofuran; Inert atmosphere; Reflux;

DOI:10.1002/adsc.200800630

upstream raw materials:

2-(1-hydroxyethyl)-4-methoxyphenol

p-methoxyphenyl (trimethylsilyl)methyl ether

5-methoxybenzofuran

2-hydroxy-5-methoxybenzaldehyde

Downstream raw materials:

2-ethyl-4-methoxy-phenylamine