Technology Process of Acetic acid (1S,2S,3R,5S)-2,3-diacetoxy-4-methylene-5-phenylacetylamino-cyclopentyl ester
There total 7 articles about Acetic acid (1S,2S,3R,5S)-2,3-diacetoxy-4-methylene-5-phenylacetylamino-cyclopentyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-Bu4NIO4, 2.) Na/Hg / 1.) MeOH, -20 deg C, 24 h, 2.) THF, MeOH, 0 deg C, 8 h
2: 96 percent / m-CPBA / dioxane / Ambient temperature
3: 32 percent / CF3CO3H / H2O / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h
4: 93 percent / DMAP / pyridine
5: H2 / Pd(OH)2/C / ethanol / 4 h / Ambient temperature
6: 1.) o-O2NC6H4SeCN, n-Bu3P, 2.) 30percent H2O2 / 1.) THF, room temperature, 4 h, 2.) THF, room temperature, 5 h
With
dmap; sodium amalgam; ortho-nitrophenyl selenocyanate; tributylphosphine; trifluoroacetyl peroxide; hydrogen; dihydrogen peroxide; tetrabutylammonium periodite; 3-chloro-benzenecarboperoxoic acid;
palladium dihydroxide;
In
1,4-dioxane; pyridine; ethanol; water;
DOI:10.1021/jo980050a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-Bu4NIO4, 2.) Na/Hg / 1.) MeOH, -20 deg C, 24 h, 2.) THF, MeOH, 0 deg C, 8 h
2: 96 percent / m-CPBA / dioxane / Ambient temperature
3: 32 percent / CF3CO3H / H2O / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h
4: 93 percent / DMAP / pyridine
5: H2 / Pd(OH)2/C / ethanol / 4 h / Ambient temperature
6: 1.) o-O2NC6H4SeCN, n-Bu3P, 2.) 30percent H2O2 / 1.) THF, room temperature, 4 h, 2.) THF, room temperature, 5 h
With
dmap; sodium amalgam; ortho-nitrophenyl selenocyanate; tributylphosphine; trifluoroacetyl peroxide; hydrogen; dihydrogen peroxide; tetrabutylammonium periodite; 3-chloro-benzenecarboperoxoic acid;
palladium dihydroxide;
In
1,4-dioxane; pyridine; ethanol; water;
DOI:10.1021/jo980050a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 32 percent / CF3CO3H / H2O / 1.) 0 deg C, 1 h, 2.) room temperature, 48 h
2: 93 percent / DMAP / pyridine
3: H2 / Pd(OH)2/C / ethanol / 4 h / Ambient temperature
4: 1.) o-O2NC6H4SeCN, n-Bu3P, 2.) 30percent H2O2 / 1.) THF, room temperature, 4 h, 2.) THF, room temperature, 5 h
With
dmap; ortho-nitrophenyl selenocyanate; tributylphosphine; trifluoroacetyl peroxide; hydrogen; dihydrogen peroxide;
palladium dihydroxide;
In
pyridine; ethanol; water;
DOI:10.1021/jo980050a
