(4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester

Base Information

Chemical Name:(4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester
CAS No.:442850-36-4
Molecular Formula:C₂₄H₂₁NO₄
Molecular Weight:387.435
Hs Code.:

Synonyms:

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Chemical Property of (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester

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Technology Process of (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester

There total 7 articles about (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60512-85-8
(E)-isopropyl cinnamate

: 442850-36-4
(4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / K₂OsO₂(OH)4; (DHQ)2-PHAL; LiOH

2: HCl / H₂O / 4 h / Heating

3: 1600 mg / benzene / 10 h / Heating

4: 93 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

5: 90 percent / Tf₂O; DMAP / CH₂Cl₂ / 1 h / -30 °C

6: H₂ / 10 percent Pd/C / ethyl acetate / 30 h / 20 °C

7: 612 mg / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; dmap; lithium hydroxide; potassium dioxotetrahydroxoosmate(VI); (DHQ)2-PHAL; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; benzene; 1: Sharpless aminohydroxylation;
DOI:10.1016/S0040-4020(02)00175-8

Reference yield:

: 132201-32-2,161453-08-3,949459-75-0,521059-43-8
(2R,3S)-3-phenylisoserine hydrochloride

: 442850-36-4
(4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1600 mg / benzene / 10 h / Heating

2: 93 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 90 percent / Tf₂O; DMAP / CH₂Cl₂ / 1 h / -30 °C

4: H₂ / 10 percent Pd/C / ethyl acetate / 30 h / 20 °C

5: 612 mg / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

With dmap; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; benzene;
DOI:10.1016/S0040-4020(02)00175-8

Reference yield:

: 195624-97-6
(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester

: 442850-36-4
(4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid p-methoxybenzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / H₂O / 4 h / Heating

2: 1600 mg / benzene / 10 h / Heating

3: 93 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

4: 90 percent / Tf₂O; DMAP / CH₂Cl₂ / 1 h / -30 °C

5: H₂ / 10 percent Pd/C / ethyl acetate / 30 h / 20 °C

6: 612 mg / DMAP; DCC / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; dmap; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; benzene;
DOI:10.1016/S0040-4020(02)00175-8