1-Benzyl-2-(trifluoromethyl)benzimidazole

Base Information

• Chemical Name: 1-Benzyl-2-(trifluoromethyl)benzimidazole
• CAS No.: 134275-16-4
• Molecular Formula: C15H11F3N2
• Molecular Weight: 276.261
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID401215096
• Nikkaji Number: J2.455.712J
• Mol file: 134275-16-4.mol

Synonyms:1-benzyl-2-(trifluoromethyl)benzimidazole;134275-16-4;C15H11F3N2;1-benzyl-2-(trifluoromethyl)-1H-1,3-benzimidazole;BAS 07328058;IFLab1_006313;DTXSID401215096;HMS1429O21;MFCD00900547;STK738192;AKOS000565583;1-benzyl-2-(trifluoromethyl)-1H-benzimidazole;1-Benzyl-2-(trifluoromethyl)-1H-benzoimidazole;1H-Benzoimidazole, 1-benzyl-2-trifluoromethyl-;2R-1528;1-benzyl-2-(trifluoromethyl)-1H-1,3-benzodiazole;1-Benzyl-2-(trifluoromethyl)-1H-benzo[d]imidazole;1-(Phenylmethyl)-2-(trifluoromethyl)-1H-benzimidazole;Z25947104

Chemical Property of 1-Benzyl-2-(trifluoromethyl)benzimidazole

Chemical Property:

• PSA: 17.82000
• LogP: 4.10340
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 276.08743285
• Heavy Atom Count: 20
• Complexity: 326

Purity/Quality:

96% ^*data from raw suppliers

1-Benzyl-2-(trifluoromethyl)benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2C(F)(F)F

Technology Process of 1-Benzyl-2-(trifluoromethyl)benzimidazole

There total 11 articles about 1-Benzyl-2-(trifluoromethyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chloride (1160967-80-5) + benzylamine (100-46-9) → 1-benzyl-2-(trifluoromethyl)-1H-benzo[d]imidazole (134275-16-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1016/j.mcat.2021.111767

Reference yield: 99.0%

→ 1-benzyl-2-(trifluoromethyl)-1H-benzo[d]imidazole (134275-16-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Schlenk technique;

Reference yield: 92.0%

benzyl bromide (100-39-0) + 1-(tri-n-butylstannyl)-2-trifluoromethylbenzimidazole → 1-benzyl-2-(trifluoromethyl)-1H-benzo[d]imidazole (134275-16-4)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 1.5h; Product distribution; var. solvents;

DOI:10.1016/0022-328X(92)83130-A

upstream raw materials:

benzyl bromide

benzyl chloride

2,2,2-trifluoro-N-(2-iodophenyl)acetamide

benzylamine