1H-Pyrrole-2-carbonitrile, 1-(2,3-difluorophenyl)-

Base Information

Chemical Name:1H-Pyrrole-2-carbonitrile, 1-(2,3-difluorophenyl)-
CAS No.:195711-25-2
Molecular Formula:C₁₁H₆F₂N₂
Molecular Weight:204.179
Hs Code.:
DSSTox Substance ID:DTXSID801226835

Synonyms:1H-Pyrrole-2-carbonitrile, 1-(2,3-difluorophenyl)-;195711-25-2;DTXSID801226835

Suppliers and Price of 1H-Pyrrole-2-carbonitrile, 1-(2,3-difluorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrole-2-carbonitrile, 1-(2,3-difluorophenyl)-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:204.04990452
Heavy Atom Count:15
Complexity:273

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)F)F)N2C=CC=C2C#N

Technology Process of 1H-Pyrrole-2-carbonitrile, 1-(2,3-difluorophenyl)-

There total 2 articles about 1H-Pyrrole-2-carbonitrile, 1-(2,3-difluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4519-40-8
2,3-difluoroanilline

: 195711-25-2
1-(2,3-difluorophenyl)-1H-pyrrole-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / acetic acid / 1 h / Heating

2: 1.) DMF, 2.) NH₂OH*HCl, NaOAc, 3.) Ac₂O

With hydroxylamine hydrochloride; sodium acetate; acetic anhydride; N,N-dimethyl-formamide; In acetic acid;
DOI:10.1021/jm970376w

Reference yield:

: 79-37-8
oxalyl dichloride

: 195711-22-9
1-(2,3-difluorophenyl)-1H-pyrrole

: 195711-25-2
1-(2,3-difluorophenyl)-1H-pyrrole-2-carbonitrile

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; acetic anhydride; N,N-dimethyl-formamide; Yield given. Multistep reaction;
DOI:10.1021/jm970376w