1α-dihydroxy-26,27-dimethylvitamin D₃

Base Information

Chemical Name:1α-dihydroxy-26,27-dimethylvitamin D₃
CAS No.:106372-44-5
Molecular Formula:C₂₉H₄₈O₂
Molecular Weight:428.699
Hs Code.:

1α-dihydroxy-26,27-dimethylvitamin D<sub>3</sub>

Synonyms:

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Chemical Property of 1α-dihydroxy-26,27-dimethylvitamin D₃

Chemical Property:

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Technology Process of 1α-dihydroxy-26,27-dimethylvitamin D₃

There total 15 articles about 1α-dihydroxy-26,27-dimethylvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5255-17-4
3β-hydroxy-5-cholenoic acid

: 106372-44-5
1α-dihydroxy-26,27-dimethylvitamin D₃

Guidance literature:: Multi-step reaction with 15 steps

1: lithium aluminum hydride / tetrahydrofuran / 18 h / 60 °C

2: dichlorodicyanobenzoquinone / dioxane / 15 h / Ambient temperature

3: p-toluenesulfonic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 72 percent / sodium hydroxide, hydrogen peroxide / methanol; H₂O / 1.5 h / Ambient temperature

5: lithium / liquid ammonia; tetrahydrofuran / 1.5 h / -78 °C

6: N,N-diethylcyclohexylamine / dioxane / 1.) 50 deg C, 6 h; 2.) 80 deg C, 2 h

7: aq. HCl; tetrahydrofuran; methanol / Ambient temperature

8: 73 percent / pyridine / 0.5 h / 0 °C

9: 93 percent / Li₂CuCl₄ / tetrahydrofuran / 1 h / 0 °C

10: 52 percent / methanol; aq. HCl / 3 h / Heating

11: 95 percent / pyridine / 4-dimethylaminopyridine / 4 h / Ambient temperature

12: N-bromosuccinimide / CCl₄ / 0.5 h / Heating

13: tetra-n-butylammonium fluoride / tetra-n-butylammonium bromide / tetrahydrofuran / Ambient temperature

14: potassium hydroxide / methanol; tetrahydrofuran

With pyridine; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; dilithium tetrachlorocuprate; diethyl-cyclohexyl-amine; tetrabutyl ammonium fluoride; dihydrogen peroxide; lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; dmap; tetrabutylammomium bromide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; tetrachloromethane; dichloromethane; ammonia; water;
DOI:10.1248/cpb.36.2303

Reference yield:

: 54668-67-6
3β,24-dihydroxychol-5-ene

: 106372-44-5
1α-dihydroxy-26,27-dimethylvitamin D₃

Guidance literature:: Multi-step reaction with 14 steps

1: dichlorodicyanobenzoquinone / dioxane / 15 h / Ambient temperature

2: p-toluenesulfonic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 72 percent / sodium hydroxide, hydrogen peroxide / methanol; H₂O / 1.5 h / Ambient temperature

4: lithium / liquid ammonia; tetrahydrofuran / 1.5 h / -78 °C

5: N,N-diethylcyclohexylamine / dioxane / 1.) 50 deg C, 6 h; 2.) 80 deg C, 2 h

6: aq. HCl; tetrahydrofuran; methanol / Ambient temperature

7: 73 percent / pyridine / 0.5 h / 0 °C

8: 93 percent / Li₂CuCl₄ / tetrahydrofuran / 1 h / 0 °C

9: 52 percent / methanol; aq. HCl / 3 h / Heating

10: 95 percent / pyridine / 4-dimethylaminopyridine / 4 h / Ambient temperature

11: N-bromosuccinimide / CCl₄ / 0.5 h / Heating

12: tetra-n-butylammonium fluoride / tetra-n-butylammonium bromide / tetrahydrofuran / Ambient temperature

13: potassium hydroxide / methanol; tetrahydrofuran

With pyridine; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; dilithium tetrachlorocuprate; diethyl-cyclohexyl-amine; tetrabutyl ammonium fluoride; dihydrogen peroxide; lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; dmap; tetrabutylammomium bromide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; tetrachloromethane; dichloromethane; ammonia; water;
DOI:10.1248/cpb.36.2303

Reference yield:

: 106372-41-2
1α,3β-bis(methoxymethoxy)chol-5-en-24-ol

: 106372-44-5
1α-dihydroxy-26,27-dimethylvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / pyridine / 0.5 h / 0 °C

2: 93 percent / Li₂CuCl₄ / tetrahydrofuran / 1 h / 0 °C

3: 52 percent / methanol; aq. HCl / 3 h / Heating

4: 95 percent / pyridine / 4-dimethylaminopyridine / 4 h / Ambient temperature

5: N-bromosuccinimide / CCl₄ / 0.5 h / Heating

6: tetra-n-butylammonium fluoride / tetra-n-butylammonium bromide / tetrahydrofuran / Ambient temperature

7: potassium hydroxide / methanol; tetrahydrofuran

With pyridine; potassium hydroxide; N-Bromosuccinimide; dilithium tetrachlorocuprate; tetrabutyl ammonium fluoride; dmap; tetrabutylammomium bromide; In tetrahydrofuran; hydrogenchloride; methanol; tetrachloromethane;
DOI:10.1248/cpb.36.2303