1-(4-Hydroxyphenyl)Guanidine Hydrochloride

Base Information

• Chemical Name: 1-(4-Hydroxyphenyl)Guanidine Hydrochloride
• CAS No.: 24067-10-5
• Molecular Formula: C7H9 N3 O . Cl H
• Molecular Weight: 187.629
• ChEMBL ID: CHEMBL2323124
• DSSTox Substance ID: DTXSID50946909
• Mol file: 24067-10-5.mol

Synonyms:1-(4-Hydroxyphenyl)Guanidine Hydrochloride;CHEMBL2323124;24067-10-5;SCHEMBL1593109;DTXSID50946909;IFHCVRXNEVZWKB-UHFFFAOYSA-N;1-(4-Hydroxyphenyl)Guanidine HCl;AKOS038555735;N-(4-hydroxy-phenyl)-guanidine hydrochloride;N-(4-Hydroxyphenyl)guanidine--hydrogen chloride (1/1)

Chemical Property of 1-(4-Hydroxyphenyl)Guanidine Hydrochloride

Chemical Property:

• Vapor Pressure: 1.59E-06mmHg at 25°C
• Boiling Point: 386.5°C at 760 mmHg
• Flash Point: 187.5°C
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 187.0512396
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N=C(N)N)O.Cl

Technology Process of 1-(4-Hydroxyphenyl)Guanidine Hydrochloride

There total 1 articles about 1-(4-Hydroxyphenyl)Guanidine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CYANAMID (420-04-2) + p-aminophenol hydrochloride (51-78-5) → (4-hydroxy-phenyl)-guanidine; hydrochloride (24067-10-5)

Guidance literature:

DOI:10.1248/cpb.32.4466

Reference yield:

(E)-3-(dimethylamino)-1-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one (1225586-32-2) + (4-hydroxy-phenyl)-guanidine; hydrochloride (24067-10-5) → 4-[4-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino]phenol (1225584-88-2)

Guidance literature:

With sodium hydroxide; In methanol; ethanol; at 150 ℃; for 0.416667h; microwave irradiation;

Reference yield:

(E)-1-(7-chloro-1-ethyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-3-(dimethylamino)prop-2-en-1-one (1225586-50-4) + (4-hydroxy-phenyl)-guanidine; hydrochloride (24067-10-5) → 4-(4-(7-chloro-1-ethyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-ylamino)phenol (1225585-67-0)

Guidance literature:

With sodium hydroxide; In ethanol; acetonitrile; at 150 ℃; for 0.416667h; Microwave irradiation;

upstream raw materials:

CYANAMID

p-aminophenol hydrochloride

Downstream raw materials:

4-[4-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino]phenol

4-(4-(7-chloro-1-ethyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-ylamino)phenol