6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde

Base Information

Chemical Name:6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde
CAS No.:134670-30-7
Molecular Formula:C12H7FN2OS
Molecular Weight:246.265
Hs Code.:2934100090
European Community (EC) Number:673-832-0
DSSTox Substance ID:DTXSID70374644
Wikidata:Q82163244
ChEMBL ID:CHEMBL1910359
Mol file:134670-30-7.mol

Synonyms:134670-30-7;6-(4-fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde;6-(4-fluorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde;6-(4-Fluorophenyl)imidazo[2,1-b]thiazole-5-carboxaldehyde;6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-carbaldehyde;SCHEMBL4771935;CHEMBL1910359;DTXSID70374644;NMJLTWCGJYJVDO-UHFFFAOYSA-N;BBL022346;MFCD00268731;STK786611;AKOS000749048;CS-0312709;FT-0737693;D95939;12R-0213;F1996-0025;Z111566950;6-(4-fluorophenyl) imidazo[2,1-b]thiazol-5-carbaldehyde;6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde, AldrichCPR

Suppliers and Price of 6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde
500mg
$ 155.00

Matrix Scientific
6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde
1g
$ 215.00

Matrix Scientific
6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde
500mg
$ 107.00

Matrix Scientific
6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde
5g
$ 856.00

Crysdot
6-(4-Fluorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde 95+%
5g
$ 377.00

CHESS?
BA010008:6-(4-Fluoro-phenyl)-imidazo[2,1-b]thiazole-5-carbaldehyde 97
5 g
$ 900.00

American Custom Chemicals Corporation
6-(4-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE 95.00%
5G
$ 4966.50

Total 16 raw suppliers

Chemical Property of 6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde

Chemical Property:

Refractive Index:1.698
PKA:2.98±0.40(Predicted)
PSA：62.61000
Density:1.44 g/cm³
LogP:3.01440
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:246.02631219
Heavy Atom Count:17
Complexity:296

Purity/Quality:

98%min ^*data from raw suppliers

6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=C(N3C=CSC3=N2)C=O)F

Technology Process of 6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde

There total 4 articles about 6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 7025-29-8
6-p-fluorophenylimidazo<2,1-b>thiazole

: 134670-30-7
6-(4-fluorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde

Guidance literature:: With trichlorophosphate; In chloroform; at 0 - 20 ℃; Reflux;
DOI:10.1039/d0md00188k

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 134670-30-7
6-(4-fluorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetone / Reflux

2.1: hydrogenchloride / water / 1 h / Reflux

3.1: trichlorophosphate / chloroform / 0 - 5 °C

3.2: 20 °C / Reflux

3.3: Cooling with ice

With hydrogenchloride; trichlorophosphate; In chloroform; water; acetone; 3.1: Vilsmeier formylation / 3.2: Vilsmeier formylation / 3.3: Vilsmeier formylation;
DOI:10.1002/cmdc.201000346

Reference yield:

: 5068-71-3
2-amino-3-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-thiazolium; bromide

: 134670-30-7
6-(4-fluorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 1 h / Reflux

2.1: trichlorophosphate / chloroform / 0 - 5 °C

2.2: 20 °C / Reflux

2.3: Cooling with ice

With hydrogenchloride; trichlorophosphate; In chloroform; water; 2.1: Vilsmeier formylation / 2.2: Vilsmeier formylation / 2.3: Vilsmeier formylation;
DOI:10.1002/cmdc.201000346