[4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone

Base Information

• Chemical Name: [4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone
• CAS No.: 1310876-59-5
• Molecular Formula: C₂₉H₂₃ClN₄O₅
• Molecular Weight: 542.978
• Mol file: 1310876-59-5.mol

Synonyms:

Chemical Property of [4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone

There total 4 articles about [4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-hydroxy-2-oxo-2-phenylethanimidoyl chloride (4937-87-5) + (E)-1-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]iso-quinolin-3-yl)-3-(dimethylamino)prop-2-en-1-one (1310876-28-8) → [4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone (1310876-59-5)

Guidance literature:

In acetonitrile; at 20 ℃; for 3h;

DOI:10.1515/znb-2011-0313

Reference yield:

6,7-dimethoxy-3,4-dihydro-isoquinoline (3382-18-1) → [4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone (1310876-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: chitosan / ethanol / 0.17 h / 80 °C / 8400.84 Torr / Microwave irradiation

2: 4 h / Reflux

3: acetonitrile / 3 h / 20 °C

With chitosan; In ethanol; acetonitrile;

DOI:10.1515/znb-2011-0313

Reference yield:

2-oxo-N-(4-chlorophenyl)propanehydrazonoyl chloride (18247-78-4,1338563-31-7) → [4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl]phenylmethanone (1310876-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: chitosan / ethanol / 0.17 h / 80 °C / 8400.84 Torr / Microwave irradiation

2: 4 h / Reflux

3: acetonitrile / 3 h / 20 °C

With chitosan; In ethanol; acetonitrile;

DOI:10.1515/znb-2011-0313

upstream raw materials:

N-hydroxy-2-oxo-2-phenylethanimidoyl chloride

(E)-1-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]iso-quinolin-3-yl)-3-(dimethylamino)prop-2-en-1-one

1,5,6,10b-tetrahydro-1-(4-chlorophenyl)-3-acetyl-8,9-dimethoxy[1,2,4]triazolo-[3,4-a]isoquinoline

6,7-dimethoxy-3,4-dihydro-isoquinoline