N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

Base Information

Chemical Name:N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide
CAS No.:128972-37-2
Molecular Formula:C₃₈H₅₀N₆O₂
Molecular Weight:622.854
Hs Code.:

N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

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Chemical Property of N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

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Technology Process of N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

There total 12 articles about N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3099-31-8
nicotinyl chloride

: 128972-37-2,129096-87-3
N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) 2 h

2: 2 M aq. NaOH / ethanol / 1 h

3: 1-hydroxybenzotriazole (HOBT), triethylamine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

With sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005

Reference yield:

: 108-85-0
1-bromocyclohexane

: 128972-37-2,129096-87-3
N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg / 1.) ether, 2.) from -20 deg C to RT, 18 h

2: HCl / dioxane

3: 1-hydroxybenzotriazole (HOBT), triethylamine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 128972-37-2,129096-87-3
N-((1S,2S)-2-Cyclohexyl-1-cyclohexylmethyl-2-hydroxy-ethyl)-2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg / 1.) ether, 2.) from -20 deg C to RT, 18 h

2: HCl / dioxane

3: 1-hydroxybenzotriazole (HOBT), triethylamine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005