sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate

Base Information

Chemical Name:sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate
CAS No.:147933-37-7
Molecular Formula:C₂₃H₂₂N₅O₂*Na
Molecular Weight:423.45
Hs Code.:

Synonyms:sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate

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Chemical Property of sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate

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Technology Process of sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate

There total 8 articles about sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3099-31-8
nicotinyl chloride

: 147933-37-7
sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) 2 h

2: 2 M aq. NaOH / ethanol / 1 h

With sodium hydroxide; sodium hydride; In ethanol;
DOI:10.1021/jm00171a005

Reference yield:

: 128972-17-8
ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

: 147933-37-7
sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate

Guidance literature:: With sodium hydroxide; In ethanol; for 1h;
DOI:10.1021/jm00171a005

Reference yield:

: 130227-97-3
2-chloro-3-propyl-5-(pyridin-3-yl)pyrazine

: 147933-37-7
sodium 2-[8-isobutyl-6-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: H₂N-NH₂*H₂O / dimethylsulfoxide / 3 h / Heating

2: ethyl acetate / 1 h / 0 °C

3: p-toluenesulfonic acid monohydrate (PTSA) / toluene / 2.5 h / Heating

4: 1.) NaH / 1.) DMF, 0 deg C, 2.) 2 h

5: 2 M aq. NaOH / ethanol / 1 h

With sodium hydroxide; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; In ethanol; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1021/jm00171a005