Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate

Base Information

• Chemical Name: Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate
• CAS No.: 130713-60-9
• Molecular Formula: C₁₆H₂₆O₆
• Molecular Weight: 314.379
• Mol file: 130713-60-9.mol

Synonyms:

Chemical Property of Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate

There total 5 articles about Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate (130713-60-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) LDA / 1) THF, -78 to -20 deg C, 2) -20 to 20 deg C

2: aq. KOH / tetrahydrofuran

3: 98 percent / H₂ / Rh/C / propan-2-ol

4: 1) 20 deg C

With potassium hydroxide; hydrogen; lithium diisopropyl amide; Rh on carbon; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1016/S0040-4039(00)61770-7

Reference yield:

(R)-2-Benzyl-3-hydroxy-succinic acid diisopropyl ester (117471-08-6,127781-27-5) → Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate (130713-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. KOH / tetrahydrofuran

2: 98 percent / H₂ / Rh/C / propan-2-ol

3: 1) 20 deg C

With potassium hydroxide; hydrogen; Rh on carbon; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1016/S0040-4039(00)61770-7

Reference yield:

2R-hydroxy-3S-(phenylmethyl)butanedioic acid (130713-47-2) → Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate (130713-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / H₂ / Rh/C / propan-2-ol

2: 1) 20 deg C

With hydrogen; Rh on carbon; In isopropyl alcohol;

DOI:10.1016/S0040-4039(00)61770-7

upstream raw materials:

(2S,3R)-2-Cyclohexylmethyl-3-hydroxy-succinic acid

acetyl chloride

isopropyl alcohol

benzyl bromide

Downstream raw materials:

(2R,3S)-2-Acetoxy-3-cyclohexylmethyl-succinamic acid isopropyl ester

2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester

(2R,3S)-2-Acetoxy-3-tert-butoxycarbonylamino-4-cyclohexyl-butyric acid isopropyl ester