6-(tert-butyl)-2-chloronicotinaldehyde

Base Information

Chemical Name:6-(tert-butyl)-2-chloronicotinaldehyde
CAS No.:910487-07-9
Molecular Formula:C₁₀H₁₂ClNO
Molecular Weight:197.664
Hs Code.:

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Chemical Property of 6-(tert-butyl)-2-chloronicotinaldehyde

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Technology Process of 6-(tert-butyl)-2-chloronicotinaldehyde

There total 3 articles about 6-(tert-butyl)-2-chloronicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4138-20-9
6-tert-butyl-2-chloro-pyridine-3-carbonitrile

: 910487-07-9
6-(tert-butyl)-2-chloronicotinaldehyde

Guidance literature:: 6-tert-butyl-2-chloro-pyridine-3-carbonitrile; With diisobutylaluminium hydride; In diethyl ether; toluene; at -78 - 20 ℃; for 2h;

With water; Rochelle's salt; In diethyl ether; toluene;

Reference yield: 50.0%

: 97691-23-1
2-(tert-butyl)-6-chloropyridine

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 910487-07-9
6-(tert-butyl)-2-chloronicotinaldehyde

Guidance literature:: 2-(tert-butyl)-6-chloropyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 2402-78-0
2,6-dichloropyridine

: 910487-07-9
6-(tert-butyl)-2-chloronicotinaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; lithium bromide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 12 h / -78 - 20 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; lithium bromide; In tetrahydrofuran;
DOI:10.1021/jacs.8b09739