C₃₁H₄₀N₅O₁₆PS

Base Information

• Chemical Name: C₃₁H₄₀N₅O₁₆PS
• CAS No.: 295311-86-3
• Molecular Formula: C₃₁H₄₀N₅O₁₆PS
• Molecular Weight: 801.722
• Mol file: 295311-86-3.mol

Synonyms:

Chemical Property of C₃₁H₄₀N₅O₁₆PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₄₀N₅O₁₆PS

There total 8 articles about C₃₁H₄₀N₅O₁₆PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → C31H40N5O16PS (295311-86-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dicyclohexylcarbodiimide / diethyl ether / 3 h / 20 °C

1.2: N-methylimidazole / pyridine / 0.5 h

2.1: 0.22 g / acetic acid; H₂O / 2 h / 40 °C

3.1: 75 percent / triisopropylbenzenesulfonyl chloride; M-methylimidazole / pyridine

4.1: CsF / acetonitrile / 0.33 h / 50 °C

5.1: N₂H₄*H₂O

6.1: dichloroacetic acid / CH₂Cl₂ / 0.02 h

With 1-methyl-1H-imidazole; dichloro-acetic acid; triisopropylbenzenesulfonyl chloride; hydrazine hydrate; dicyclohexyl-carbodiimide; cesium fluoride; In pyridine; diethyl ether; dichloromethane; water; acetic acid; acetonitrile; 1.1: Addition / 1.2: Condensation / 2.1: acidolysis / 3.1: Esterification / 4.1: transesterification / 5.1: hyrazinolysis / 6.1: acidolysis;

DOI:10.1007/BF02786343

Reference yield:

6-nitroveratrylbromide (53413-67-5) → C31H40N5O16PS (295311-86-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / aq. NaOH / ethanol / 0.5 h

2: CsF / acetonitrile / 0.33 h / 50 °C

3: N₂H₄*H₂O

4: dichloroacetic acid / CH₂Cl₂ / 0.02 h

With dichloro-acetic acid; sodium hydroxide; hydrazine hydrate; cesium fluoride; In ethanol; dichloromethane; acetonitrile; 1: Substitution / 2: transesterification / 3: hyrazinolysis / 4: acidolysis;

DOI:10.1007/BF02786343

Reference yield:

3'-O-levulinoylthymidine (78635-98-0) → C31H40N5O16PS (295311-86-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / triisopropylbenzenesulfonyl chloride; M-methylimidazole / pyridine

2: CsF / acetonitrile / 0.33 h / 50 °C

3: N₂H₄*H₂O

4: dichloroacetic acid / CH₂Cl₂ / 0.02 h

With 1-methyl-1H-imidazole; dichloro-acetic acid; triisopropylbenzenesulfonyl chloride; hydrazine hydrate; cesium fluoride; In pyridine; dichloromethane; acetonitrile; 1: Esterification / 2: transesterification / 3: hyrazinolysis / 4: acidolysis;

DOI:10.1007/BF02786343

upstream raw materials:

6-nitroveratrylbromide

3'-O-levulinoylthymidine

5'-O-(4,4'-dimethoxytrityl)-3'-O-levulinoyl-2'-deoxythymidine

4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate